EP 3638669 A1 20200422 - SUBSTITUTED PYRROLOPYRIDINE-DERIVATIVES
Title (en)
SUBSTITUTED PYRROLOPYRIDINE-DERIVATIVES
Title (de)
SUBSTITUIERTE PYRROLOPYRIDINDERIVATE
Title (fr)
DÉRIVÉS DE PYRROLOPYRIDINE SUBSTITUÉS
Publication
Application
Priority
- EP 17175861 A 20170613
- EP 2018065036 W 20180607
Abstract (en)
[origin: WO2018228920A1] The present invention relates to protein-inhibitory substituted pyrrolopyridine derivatives of formula (I) in which X, Y, R1, R2, R3 and R4 are as defined herein, to pharmaceutical compositions and combinations comprising the compounds according to the invention, and to the prophylactic and therapeutic use of the inventive compounds, respectively to the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for neoplastic disorders, repectively cancer or conditions with dysregulated immune responses or other disorders associated with aberrant MAP4K1 signaling, as a sole agent or in combination with other active ingredients. The present invention further relates to the use, respectively to the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of protein inhibitors in benign hyperplasias, atherosclerotic disorders, sepsis, autoimmune disorders, vascular disorders, viral infections, in neurodegenerative disorders, in inflammatory disorders, in atherosclerotic disorders and in male fertility control.
IPC 8 full level
A61P 35/00 (2006.01); C07D 471/04 (2006.01)
CPC (source: EP)
A61P 35/00 (2017.12); C07D 471/04 (2013.01)
Citation (search report)
See references of WO 2018228920A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2018228920 A1 20181220; CA 3066859 A1 20181220; EP 3638669 A1 20200422
DOCDB simple family (application)
EP 2018065036 W 20180607; CA 3066859 A 20180607; EP 18728901 A 20180607