EP 3638776 A1 20200422 - METHODS AND MEANS FOR GENETIC ALTERATION OF GENOMES UTILIZING DESIGNER DNA RECOMBINING ENZYMES
Title (en)
METHODS AND MEANS FOR GENETIC ALTERATION OF GENOMES UTILIZING DESIGNER DNA RECOMBINING ENZYMES
Title (de)
VERFAHREN UND MITTEL ZUR GENETISCHEN VERÄNDERUNG VON GENOMEN UNTER VERWENDUNG VON DESIGNER-DNA-REKOMBINATIOSENZYMEN
Title (fr)
PROCÉDÉS ET MOYENS DE MODIFICATION GÉNÉTIQUE DE GÉNOMES FAISANT APPEL À DES ENZYMES DE RECOMBINAISON D'ADN DE CONCEPTION
Publication
Application
Priority
- EP 17175895 A 20170614
- EP 2018065881 W 20180614
Abstract (en)
[origin: WO2018229226A1] The invention provides methods and means for specifically altering the DNA sequence in a genome, in particular for genome editing by deleting or replacing a sequence of interest. Advantageously, the invention uses two non-identical sequences naturally occurring in a genome as target sites two which DNA-recombining enzymes are generated. The invention is in particular useful for medicine, in particular to repair a mutation in a genome or to delete predefined genetic material from cells or tissue and to cure diseases. An advantage of the invention is that it allows precise site directed altering of DNA without engaging host DNA repair pathways and thereby works without inducing random insertions and deletions (indels).
IPC 8 full level
C12N 9/00 (2006.01); C12N 9/12 (2006.01); C12N 9/22 (2006.01); C12N 15/10 (2006.01); C12N 15/90 (2006.01)
CPC (source: EP US)
C12N 9/00 (2013.01 - EP); C12N 9/1241 (2013.01 - EP); C12N 9/22 (2013.01 - EP US); C12N 15/1058 (2013.01 - EP US); C12N 15/902 (2013.01 - EP); C12N 15/907 (2013.01 - US); C12Q 1/6869 (2013.01 - US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2018229226 A1 20181220; CA 3066047 A1 20181220; CN 110914414 A 20200324; EP 3638776 A1 20200422; JP 2020527938 A 20200917; JP 2023116580 A 20230822; JP 7402503 B2 20231221; US 11845954 B2 20231219; US 2021147878 A1 20210520; US 2023235364 A1 20230727
DOCDB simple family (application)
EP 2018065881 W 20180614; CA 3066047 A 20180614; CN 201880039699 A 20180614; EP 18731446 A 20180614; JP 2019568653 A 20180614; JP 2023092153 A 20230605; US 201816622937 A 20180614; US 202218046066 A 20221012