Global Patent Index - EP 3639822 A1

EP 3639822 A1 20200422 - COMPOUND FOR USE IN THE TREATMENT OF A DISEASE CHARACTERIZED BY DYSREGULATED MUCUS PRODUCTION AND/OR SECRETION

Title (en)

COMPOUND FOR USE IN THE TREATMENT OF A DISEASE CHARACTERIZED BY DYSREGULATED MUCUS PRODUCTION AND/OR SECRETION

Title (de)

VERBINDUNG ZUR VERWENDUNG BEI DER BEHANDLUNG EINER DURCH EINE DYSREGULIERTE SCHLEIMPRODUKTION UND/ODER SEKRETION GEKENNZEICHNETEN KRANKHEIT

Title (fr)

COMPOSÉ DESTINÉ À ÊTRE UTILISÉ DANS LE TRAITEMENT D'UNE MALADIE CARACTÉRISÉE PAR UN DÉRÈGLEMENT DE LA PRODUCTION ET/OU SÉCRÉTION DE MUCUS

Publication

EP 3639822 A1 20200422 (EN)

Application

EP 18200399 A 20181015

Priority

EP 18200399 A 20181015

Abstract (en)

The present invention relates to a compound for use in a method of treating a disease selected from cystic fibrosis, ulcerative colitis, and irritable bowel syndrome, wherein said compound is an inhibitor of a TMEM16 protein, preferably of TMEM16A and/or TMEM16F.

IPC 8 full level

A61K 31/426 (2006.01); A61K 31/122 (2006.01); A61K 31/167 (2006.01); A61K 31/343 (2006.01); A61P 1/00 (2006.01); A61P 11/00 (2006.01)

CPC (source: EP US)

A61K 31/122 (2013.01 - EP US); A61K 31/167 (2013.01 - EP US); A61K 31/343 (2013.01 - EP US); A61K 31/426 (2013.01 - EP US); A61P 11/12 (2017.12 - EP)

Citation (applicant)

  • HUANG F; ZHANG H; WU M; YANG H; KUDO M; PETERS CJ ET AL.: "Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction", PROC. NATL. ACAD. SCI U. S. A, vol. 109, 2012, pages 16354 - 9, XP055509245, DOI: doi:10.1073/pnas.1214596109
  • LIN J; JIANG Y; LI L; LIU Y; TANG H ET AL.: "TMEM16A mediates the hypersecretion of mucus induced by Interleukin-13", EXP CELL RES, 2015, pages 260 - 269, XP029577662, DOI: doi:10.1016/j.yexcr.2015.02.026
  • MINER K; LIU B; WANG P; LABITZKE K; GAIDA K ET AL.: "The antihelminthic niclosamide is a potent TMEM16A antagonist that fully bronchodilates airways", BIORXIV, 2018, Retrieved from the Internet <URL:https://doi.org/1o.1101/254888>

Citation (search report)

  • [XI] US 2017290812 A1 20171012 - DARTEIL RAPHAEL [FR], et al
  • [X] US 2017056347 A1 20170302 - GLICK GARY D [US], et al
  • [XI] WO 2018026441 A1 20180208 - UNIV CALIFORNIA [US]
  • [XI] US 2006160867 A1 20060720 - FREEDMAN STEVEN D [US]
  • [X] DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; October 2009 (2009-10-01), EIDELWEIN ALEXANDRA ET AL: "Nitazoxanide to Treat Exacerbations of Pediatric Inflammatory Bowel Disease (IBD)", XP009512545, Database accession no. PREV201000112965 & AMERICAN JOURNAL OF GASTROENTEROLOGY, vol. 104, no. Suppl. 3, October 2009 (2009-10-01), 74TH ANNUAL SCIENTIFIC MEETING AND POSTGRADUATE COURSE OF THE AMERICAN-COLLEGE-OF-GASTROENTEROLOGY; SAN DIEGO, CA, USA; OCTOBER 23 -28, 2009, pages S545, ISSN: 0002-9270
  • [X] DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; October 2009 (2009-10-01), STUPPY WILLIAM: "Nitazoxanide for the Treatment of Blastocystis hominis in Patients with Irritable Bowel Syndrome", XP009512544, Database accession no. PREV201000112836 & AMERICAN JOURNAL OF GASTROENTEROLOGY, vol. 104, no. Suppl. 3, October 2009 (2009-10-01), 74TH ANNUAL SCIENTIFIC MEETING AND POSTGRADUATE COURSE OF THE AMERICAN-COLLEGE-OF-GASTROENTEROLOGY; SAN DIEGO, CA, USA; OCTOBER 23 -28, 2009, pages S493, ISSN: 0002-9270
  • [A] WAN NAMKUNG ET AL.: "TMEM16A Inhibitors Reveal TMEM16A as a Minor Component of Calcium-activated Chloride Channel Conductance in Airway and Intestinal Epithelial Cells*", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 286, no. 3, 21 January 2011 (2011-01-21), pages 2365 - 2374, XP002790464, DOI: 10.1074/jbc.M110.175109
  • [IDY] HUANG F; ZHANG H; WU M; YANG H; KUDO M; PETERS CJ ET AL.: "Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction", PROC. NATL. ACAD. SCI U. S. A, vol. 109, 2012, pages 16354 - 16359, XP055509245, DOI: 10.1073/pnas.1214596109
  • [A] YOHAN SEO ET AL.: "Inhibition of ANO1/TMEM16A Chloride Channel by Idebenone and Its Cytotoxicity to Cancer Cell Lines", PLOS ONE, vol. 10, no. 7, E133656, 21 July 2015 (2015-07-21), pages 1 - 15, XP002793318, DOI: 10.1371/journal.pone.0133656
  • [Y] LIN MENG-JUAN ET AL: "Colonic Hypermotility in a Rat Model of Irritable Bowel Syndrome Is Associated with Upregulation of TMEM16A in Myenteric Plexus", DIGESTIVE DISEASES AND SCIENCES, vol. 63, no. 12, 29 August 2018 (2018-08-29), SPRINGER NEW YORK LLC, US, pages 3329 - 3338, XP036641183, ISSN: 0163-2116, [retrieved on 20180829], DOI: 10.1007/S10620-018-5261-7
  • [A] LIN JIACHEN ET AL: "TMEM16A mediates the hypersecretion of mucus induced by Interleukin-13", EXPERIMENTAL CELL RESEARCH, vol. 334, no. 2, 10 March 2015 (2015-03-10), ELSEVIER, AMSTERDAM, NL, pages 260 - 269, XP029577662, ISSN: 0014-4827, DOI: 10.1016/J.YEXCR.2015.02.026

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Designated extension state (EPC)

BA ME

DOCDB simple family (publication)

EP 3639822 A1 20200422; EP 3843725 A1 20210707; EP 3843725 B1 20230906; US 2021283110 A1 20210916; WO 2020078813 A1 20200423

DOCDB simple family (application)

EP 18200399 A 20181015; EP 19783538 A 20191010; EP 2019077433 W 20191010; US 201917285031 A 20191010