EP 3644988 A4 20210303 - MITOKETOSCINS: MITOCHONDRIAL-BASED THERAPEUTICS TARGETING KETONE METABOLISM IN CANCER CELLS
Title (en)
MITOKETOSCINS: MITOCHONDRIAL-BASED THERAPEUTICS TARGETING KETONE METABOLISM IN CANCER CELLS
Title (de)
MITOKETOSZINE: AUF MITOCHONDRIEN BASIERENDE THERAPEUTIKA GEGEN DEN KETONMETABOLISMUS IN KREBSZELLEN
Title (fr)
MITOCÉTOSCINES : AGENTS THÉRAPEUTIQUES MITOCHONDRIAUX CIBLANT LE MÉTABOLISME DES CÉTONES DANS DES CELLULES CANCÉREUSES
Publication
Application
Priority
- US 201762524829 P 20170626
- US 2018039354 W 20180625
Abstract (en)
[origin: WO2019005698A1] The present disclosure relates to compounds that bind to at least one of ACAT1/2 and OXCT1/2 and inhibit mitochondrial ATP production, referred to herein as mitoketoscins. Methods of screening compounds for mitochondrial inhibition and anti-cancer properties are disclosed. Also described are methods of using mitoketoscins to prevent or treat cancer, bacterial infections, and pathogenic yeast, as well as methods of using mitoketoscins to provide anti-aging benefits. Specific mitoketoscin compounds are also disclosed.
IPC 8 full level
C07D 209/18 (2006.01); A61K 31/425 (2006.01); A61K 31/519 (2006.01); A61P 31/00 (2006.01); C07D 209/04 (2006.01); C07D 209/42 (2006.01); C07D 265/36 (2006.01); C07D 403/14 (2006.01); C07D 417/10 (2006.01); C07D 417/12 (2006.01); C07D 487/04 (2006.01)
CPC (source: EP IL KR US)
A61K 31/4045 (2013.01 - KR); A61P 31/04 (2018.01 - KR); A61P 31/10 (2018.01 - KR); A61P 35/00 (2018.01 - KR); C07D 209/04 (2013.01 - EP IL); C07D 209/18 (2013.01 - EP IL); C07D 209/42 (2013.01 - EP IL US); C07D 265/36 (2013.01 - EP IL US); C07D 403/14 (2013.01 - EP IL); C07D 417/10 (2013.01 - EP IL); C07D 417/12 (2013.01 - EP IL US); C07D 487/04 (2013.01 - EP IL US); C40B 30/06 (2013.01 - IL US); C40B 40/14 (2013.01 - IL US); G16C 20/50 (2019.02 - IL US)
Citation (search report)
- [A] US 2013172430 A1 20130704 - LISANTI MICHAEL P [US], et al
- [A] GARCIA-BERMUDEZ JAVIER ET AL: "Drugging ACAT1 for Cancer Therapy", MOLECULAR CELL, vol. 64, no. 5, 2016, pages 856 - 857, XP029831164, ISSN: 1097-2765, DOI: 10.1016/J.MOLCEL.2016.11.023
- See also references of WO 2019005698A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2019005698 A1 20190103; AU 2018292283 A1 20191212; AU 2018292283 B2 20200723; AU 2020257159 A1 20201119; AU 2020257159 B2 20220714; BR 112019026097 A2 20200707; CA 3064452 A1 20190103; CL 2019003708 A1 20200515; CN 110913854 A 20200324; CN 110913854 B 20230428; CO 2019014259 A2 20200401; CR 20200033 A 20200305; CU 20190106 A7 20201130; DO P2019000312 A 20200315; DO P2022000142 A 20220930; EC SP20001729 A 20200228; EP 3644988 A1 20200506; EP 3644988 A4 20210303; EP 3644988 B1 20230222; IL 270774 A 20200130; IL 292109 A 20220601; IL 292109 B1 20231001; IL 292109 B2 20240201; JP 2020525009 A 20200827; JP 7397672 B2 20231213; KR 102646172 B1 20240313; KR 20200018814 A 20200220; KR 20240038805 A 20240325; MX 2019014806 A 20200210; PE 20200295 A1 20200205; PH 12019502892 A1 20201207; RU 2020102908 A 20210727; RU 2020102908 A3 20211115; SG 11201913134U A 20200130; US 11667639 B2 20230606; US 11667640 B2 20230606; US 2020148688 A1 20200514; US 2020207775 A1 20200702; ZA 201907831 B 20220727; ZA 202101954 B 20220928
DOCDB simple family (application)
US 2018039354 W 20180625; AU 2018292283 A 20180625; AU 2020257159 A 20201023; BR 112019026097 A 20180625; CA 3064452 A 20180625; CL 2019003708 A 20191217; CN 201880042546 A 20180625; CO 2019014259 A 20191217; CR 20200033 A 20180625; CU 20190106 A 20180625; DO 2019000312 A 20191219; DO 2022000142 A 20220706; EC DI202001729 A 20200110; EP 18822701 A 20180625; IL 27077419 A 20191120; IL 29210922 A 20220410; JP 2019570935 A 20180625; KR 20207001405 A 20180625; KR 20247007593 A 20180625; MX 2019014806 A 20180625; PE 2019002554 A 20180625; PH 12019502892 A 20191220; RU 2020102908 A 20180625; SG 11201913134U A 20180625; US 201816626426 A 20180625; US 202016803628 A 20200227; ZA 201907831 A 20191126; ZA 202101954 A 20210324