EP 3645531 A1 20200506 - THIAZOLE COMPOUNDS USEFUL AS PRMT5 INHIBITORS
Title (en)
THIAZOLE COMPOUNDS USEFUL AS PRMT5 INHIBITORS
Title (de)
THIAZOLVERBINDUNGEN ALS PRMT5-INHIBITOREN
Title (fr)
COMPOSÉS THIAZOLE UTILES EN TANT QU'INHIBITEURS DE PRMT5
Publication
Application
Priority
- EP 17178851 A 20170629
- EP 2018066538 W 20180621
Abstract (en)
[origin: WO2019002074A1] The present invention provides PRMT5 inhibiting compounds of general formula (I). A compound of general formula (I), in which R1, R2, R3, R4, R5, R6, R7, L1 and L2 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of disorders, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
IPC 8 full level
C07D 417/12 (2006.01); A61K 31/427 (2006.01); A61P 35/00 (2006.01); C07D 277/56 (2006.01); C07D 417/14 (2006.01)
CPC (source: EP US)
A61K 31/427 (2013.01 - EP); A61P 35/00 (2017.12 - EP US); C07D 277/56 (2013.01 - EP US); C07D 417/12 (2013.01 - EP US); C07D 417/14 (2013.01 - EP US); A61K 45/06 (2013.01 - US)
Citation (search report)
See references of WO 2019002074A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2019002074 A1 20190103; EP 3645531 A1 20200506; US 2020123147 A1 20200423
DOCDB simple family (application)
EP 2018066538 W 20180621; EP 18731125 A 20180621; US 201816623935 A 20180621