EP 3668517 A4 20210217 - MICROPARTICLE FORMULATIONS OF ADENOSINE RECEPTOR ANTAGONISTS FOR TREATING CANCER
Title (en)
MICROPARTICLE FORMULATIONS OF ADENOSINE RECEPTOR ANTAGONISTS FOR TREATING CANCER
Title (de)
MIKROPARTIKELFORMULIERUNGEN VON ADENOSINREZEPTOR-ANTAGONISTEN ZUR BEHANDLUNG VON KREBS
Title (fr)
FORMULATIONS DE MICROPARTICULES D'ANTAGONISTES DU RÉCEPTEUR DE L'ADÉNOSINE POUR LE TRAITEMENT DU CANCER
Publication
Application
Priority
- US 201762545290 P 20170814
- US 2018046644 W 20180814
Abstract (en)
[origin: US2019046448A1] The invention provides compositions comprising microparticles wherein the microparticles comprise at least one adenosine 2a receptor antagonist (A2ARA), at least one pharmaceutically acceptable polymer and at least one pharmaceutically acceptable negatively charged agent wherein the microparticles optionally have a highly negative zeta potential of less than about −40 mV. The invention also provides pharmaceutical compositions of the microparticles of the invention and methods of using the compositions of the invention to enhance an immune response in a patient in need thereof and as anti-cancer immunotherapy.
IPC 8 full level
A61K 31/519 (2006.01); A61K 9/00 (2006.01); A61K 9/16 (2006.01); A61K 9/50 (2006.01); A61K 9/51 (2006.01); A61K 39/00 (2006.01); A61K 39/39 (2006.01); A61P 35/00 (2006.01); A61P 37/00 (2006.01)
CPC (source: EP US)
A61K 9/0024 (2013.01 - EP US); A61K 9/1635 (2013.01 - US); A61K 9/1647 (2013.01 - EP US); A61K 9/1652 (2013.01 - US); A61K 9/5153 (2013.01 - EP); A61K 31/519 (2013.01 - EP US); A61P 35/00 (2018.01 - EP US); A61P 37/00 (2018.01 - EP US)
Citation (search report)
- [X] WO 2016176558 A1 20161103 - UNIV CALIFORNIA [US], et al
- [X] US 2006099256 A1 20060511 - PRICE JAMES C [US], et al
- [A] WO 2014089160 A1 20140612 - PHOSPHOREX INC [US]
- [X] WU J-C ET AL: "EVALUATION OF THE PROPERTIES OF ETHYLCELLULOSE-CELLULOSE TRIACETATE MICROCAPSULES CONTAINING THEOPHYLLINE PREPARED BY DIFFERENT MICROENCAPSULATION TECHNIQUES", JOURNAL OF MICROENCAPSULATION, TAYLOR AND FRANCIS, BASINGSTOKE, GB, vol. 11, no. 5, 1 September 1994 (1994-09-01), pages 507 - 518, XP000460396, ISSN: 0265-2048
- See also references of WO 2019036438A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
US 10702476 B2 20200707; US 2019046448 A1 20190214; AU 2018317390 A1 20200402; CN 111093669 A 20200501; EP 3668517 A1 20200624; EP 3668517 A4 20210217; US 2021007992 A1 20210114; US 2023181469 A1 20230615; WO 2019036438 A1 20190221
DOCDB simple family (application)
US 201816103226 A 20180814; AU 2018317390 A 20180814; CN 201880059406 A 20180814; EP 18846566 A 20180814; US 2018046644 W 20180814; US 202016919614 A 20200702; US 202217867235 A 20220718