EP 3675814 A1 20200708 - COMPOSITION FOR TOPICAL TREATMENT OF NON-MICROORGANISM-CAUSED INFLAMMATORY SKIN AND MUCOUS-MEMBRANE DISEASES
Title (en)
COMPOSITION FOR TOPICAL TREATMENT OF NON-MICROORGANISM-CAUSED INFLAMMATORY SKIN AND MUCOUS-MEMBRANE DISEASES
Title (de)
ZUSAMMENSETZUNG ZUR TOPISCHEN BEHANDLUNG VON NICHT-MIKROORGANISMUS-VERURSACHTEN ENTZÜNDLICHEN HAUT- UND SCHLEIMHAUTERKRANKUNGEN
Title (fr)
COMPOSITION POUR LE TRAITEMENT TOPIQUE DE MALADIES INFLAMMATOIRES DE LA PEAU ET DES MUQUEUSES NON PROVOQUÉES PAR DES MICRO-ORGANISMES
Publication
Application
Priority
- DE 102017215154 A 20170830
- EP 2018073252 W 20180829
Abstract (en)
[origin: WO2019043064A1] The invention relates to a composition for topical treatment of non-microorganism-caused inflammatory skin and mucous membrane diseases, such as psoriasis type I and type II, preferably psoriasis vulgaris, psoriasis guttata, psoriasis nummeralis, erythrodermal psoriasis, psoriasis pustulosa; in particular neurodermitis, atopic eczema, atopic dermatitis and pytiriasis capitis, wherein the composition contains at least one lysosomotropic antiapoptotically active substance or a substance combination of at least one lysosomotropic antiapoptotically active substance and at least one antioxidatively active substance. A series of compounds can be used as a lysosomotropic antiapoptotically active substance or a substance combination of at least one lysosomotropic antiapoptotically active substance, in particular those which have, as an essential structural element, a basic, aliphatic and protonatable side chain or ring structure, a pKa value between 6 and 8.5 and an n-octanol-water distribution coefficient log P value > 4.0. These can be, for example, benzodiazapine derivatives, phenoxazine derivatives, or annule derivatives, in particular amitriptyline.
IPC 8 full level
A61K 9/00 (2006.01); A61K 31/135 (2006.01); A61K 47/06 (2006.01); A61K 47/12 (2006.01); A61K 47/38 (2006.01)
CPC (source: EP)
A61K 9/0014 (2013.01); A61K 31/135 (2013.01); A61K 31/201 (2013.01); A61K 45/06 (2013.01); A61K 47/06 (2013.01); A61K 47/12 (2013.01); A61K 47/38 (2013.01)
Citation (search report)
See references of WO 2019043064A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
DE 102017215154 A1 20190228; EP 3675814 A1 20200708; WO 2019043064 A1 20190307
DOCDB simple family (application)
DE 102017215154 A 20170830; EP 18762275 A 20180829; EP 2018073252 W 20180829