EP 3676399 A1 20200708 - COMPOSITIONS AND METHODS FOR IMMUNE REPERTOIRE SEQUENCING
Title (en)
COMPOSITIONS AND METHODS FOR IMMUNE REPERTOIRE SEQUENCING
Title (de)
ZUSAMMENSETZUNGEN UND VERFAHREN ZUR SEQUENZIERUNG DES IMMUNREPERTOIRES
Title (fr)
COMPOSITIONS ET MÉTHODES POUR SÉQUENÇAGE DE RÉPERTOIRE IMMUNOLOGIQUE
Publication
Application
Priority
- US 201762553688 P 20170901
- US 201762586129 P 20171114
- US 2018049259 W 20180831
Abstract (en)
[origin: WO2019046817A1] The present disclosure provides methods, compositions, kits, and systems useful in the determination and evaluation of the immune repertoire using genomic DNA from a biological sample. In one aspect, target-specific primer panels provide for the effective amplification of sequences of T cell receptor and/or B cell receptor chains with improved sequencing accuracy and resolution over the repertoire. Nucleic acid sequences of variable regions associated with the immune cell receptor are determined to effectively portray clonal diversity of a biological sample and/or differences associated with the immune cell repertoire of a biological sample.
IPC 8 full level
C12Q 1/686 (2018.01)
CPC (source: EP US)
C12Q 1/6806 (2013.01 - US); C12Q 1/686 (2013.01 - EP US); C12Q 1/6869 (2013.01 - US); C40B 40/08 (2013.01 - US); C40B 50/00 (2013.01 - US); C40B 50/06 (2013.01 - US); C12Q 2600/16 (2013.01 - US)
C-Set (source: EP US)
C12Q 1/686 + C12Q 2521/531 + C12Q 2525/101 + C12Q 2525/15 + C12Q 2525/191 + C12Q 2527/107 + C12Q 2535/122 + C12Q 2537/143
Citation (search report)
See references of WO 2019046817A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2019046817 A1 20190307; CN 111344416 A 20200626; EP 3676399 A1 20200708; EP 3676399 B1 20220511; EP 4212631 A1 20230719; US 11008609 B2 20210518; US 2019085374 A1 20190321; US 2021285027 A1 20210916
DOCDB simple family (application)
US 2018049259 W 20180831; CN 201880067084 A 20180831; EP 18778695 A 20180831; EP 22172110 A 20180831; US 201816120045 A 20180831; US 202117302638 A 20210507