Global Patent Index - EP 3677911 A3

EP 3677911 A3 20200729 - USE OF NON-AGONIST LIGANDS FOR SUPPRESSION OF METASTASIS

Title (en)

USE OF NON-AGONIST LIGANDS FOR SUPPRESSION OF METASTASIS

Title (de)

VERWENDUNG VON NICHT-AGONISTISCHE LIGANDEN ZUR UNTERDRÜCKUNG VON METASTASEN

Title (fr)

UTILISATION DE LIGAND NON AGONISTE POUR LA SUPPRESSION DE MÉTASTASES

Publication

EP 3677911 A3 20200729 (EN)

Application

EP 19183071 A 20190627

Priority

EP 19150179 A 20190103

Abstract (en)

The present invention relates to a non-agonist ligand specifically binding to VCAM1 (CD106), CD49d, CD29, the IL6 receptor (CD126), IL6, the IL1β receptor (IL1R1), IL1β, F11R, ICAM1, or ITGB2 for use in treatment or prevention of metastatic cancer. The method further relates to a method for assigning a likelihood of developing metastasis to a patient.

IPC 8 full level

A61K 39/00 (2006.01); G01N 33/574 (2006.01)

CPC (source: EP)

A61P 35/00 (2017.12); C07K 16/245 (2013.01); C07K 16/248 (2013.01); C07K 16/2803 (2013.01); C07K 16/2821 (2013.01); C07K 16/2836 (2013.01); C07K 16/2842 (2013.01); C07K 16/2845 (2013.01); C07K 16/2866 (2013.01); G01N 33/57415 (2013.01); C07K 2317/70 (2013.01)

Citation (search report)

  • [A] WO 2013053775 A1 20130418 - UNIV ZUERICH PROREKTORAT MNW [CH], et al
  • [A] GUO Y ET AL: "A PEPTIDE DERIVED FROM THE NONRECEPTOR BINDING REGION OF UROKINASE PLASMINOGEN ACTIVATOR (UPA) INHIBITS TUMOR PROGRESSION AND ANGIOGENESIS AND INDUCES TUMOR CELL DEATH IN VIVO", THE FASEB JOURNAL, FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY, US, vol. 14, no. 10, 1 July 2000 (2000-07-01), pages 1400 - 1410, XP002906184, ISSN: 0892-6638, DOI: 10.1096/FJ.14.10.1400
  • [A] A. OTTAIANO: "Overexpression of Both CXC Chemokine Receptor 4 and Vascular Endothelial Growth Factor Proteins Predicts Early Distant Relapse in Stage II-III Colorectal Cancer Patients", CLINICAL CANCER RESEARCH, vol. 12, no. 9, 1 May 2006 (2006-05-01), US, pages 2795 - 2803, XP055674000, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-05-2142
  • [X] XIN LU ET AL: "VCAM-1 Promotes Osteolytic Expansion of Indolent Bone Micrometastasis of Breast Cancer by Engaging 41-Positive Osteoclast Progenitors", CANCER CELL, CELL PRESS, US, vol. 20, no. 6, 2 November 2011 (2011-11-02), pages 701 - 714, XP028339552, ISSN: 1535-6108, [retrieved on 20111105], DOI: 10.1016/J.CCR.2011.11.002
  • [X] PEI-CHEN WANG ET AL: "Activation of VCAM-1 and Its Associated Molecule CD44 Leads to Increased Malignant Potential of Breast Cancer Cells", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 15, no. 3, 27 February 2014 (2014-02-27), pages 3560 - 3579, XP055674413, DOI: 10.3390/ijms15033560

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Designated extension state (EPC)

BA ME

DOCDB simple family (publication)

EP 3677911 A2 20200708; EP 3677911 A3 20200729

DOCDB simple family (application)

EP 19183071 A 20190627