Global Patent Index - EP 3692984 A1

EP 3692984 A1 20200812 - ANNEXIN-COATED PARTICLES

Title (en)

ANNEXIN-COATED PARTICLES

Title (de)

ANNEXINBESCHICHTETE PARTIKEL

Title (fr)

PARTICULES REVÊTUES D'ANNEXINE

Publication

EP 3692984 A1 20200812 (EN)

Application

EP 19156258 A 20190208

Priority

EP 19156258 A 20190208

Abstract (en)

The present invention relates to an annexin-coated particle, comprising a negatively charged phospholipid and an annexin non-covalently coupled thereto. The present invention further relates to a composition comprising an annexin-coated particle. Furthermore, the present invention relates to a product for use in a method of preventing or treating a disease selected from a chronic inflammatory disease, an autoimmune disease, an allergy, and a cancer, said product comprising an annexin-coated particle, and/or a composition. The present invention further relates to a method of preparing an annexin-coated particle.

IPC 8 full level

A61K 9/50 (2006.01); A61K 9/127 (2006.01)

CPC (source: EP US)

A61K 9/127 (2013.01 - EP); A61K 9/167 (2013.01 - US); A61K 9/5052 (2013.01 - EP); A61K 38/1709 (2013.01 - EP US); A61K 47/544 (2017.07 - US); A61P 37/06 (2017.12 - US)

Citation (applicant)

  • WO 2017211964 A1 20171214 - DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES ÖFFENTLICHEN RECHTS [DE]
  • NUCLEIC ACIDS RESEARCH, vol. 45, no. D1, 4 January 2017 (2017-01-04), pages D158 - D169
  • MORELLI A. E.; THOMSON A. W.: "Tolerogenic dendritic cells and the quest for transplant tolerance", NAT REV IMMUNOL., vol. 7, no. 8, 13 July 2007 (2007-07-13), pages 610 - 21, XP055345654, DOI: doi:10.1038/nri2132
  • MUELLER D. L.: "Mechanisms maintaining peripheral tolerance", NAT. IMMUNOL., vol. 11, 2010, pages 21 - 27, XP055090377, DOI: doi:10.1038/ni.1817
  • WEYD, H. ET AL.: "Annexin Ai on the surface of early apoptotic cells suppresses CD8+ T cell immunity", PLOS ONE, vol. 8, 2013, pages e62449
  • LINKE B. ET AL.: "The tolerogenic function of annexins on apoptotic cells is mediated by the annexin core domain", J IMMUNOL., vol. 194, no. 11, 2015, pages 5233 - 42, XP055240591, DOI: doi:10.4049/jimmunol.1401299
  • WALTHER, A.; K. RIEHEMANN; V. GERKE: "A novel ligand of the formyl peptide receptor: annexin I regulates neutrophil extravasation by interacting with the FPR", MOL CELL, vol. 5, 2000, pages 831 - 840, XP002973977, DOI: doi:10.1016/S1097-2765(00)80323-8
  • BROWN G. D.; WILLMENT J. A.; WHITEHEAD L.: "C-type lectins in immunity and homeostasis", NAT REV IMMUNOL., vol. 18, no. 6, 2018, pages 374 - 389, XP036512529, DOI: doi:10.1038/s41577-018-0004-8
  • DILLON S.R.: "Annexin V binds to viable B cells and colocalizes with a marker of lipid rafts upon B cell receptor activation", J IMMUNOL, vol. 164, 2000, pages 1322 - 1332, XP055140865, DOI: doi:10.4049/jimmunol.164.3.1322
  • RAN S. ET AL.: "Phosphatidylserine is a marker of tumor vasculature and a potential target for cancer imaging and therapy", INT J RADIAT ONCOL BIOL PHYS., vol. 54, no. 5, 2002, pages 1479 - 84, XP009082855, DOI: doi:10.1016/S0360-3016(02)03928-7
  • GARNIER B. ET AL.: "Annexin As-functionalized liposomes for targeting phosphatidylserine-exposing membranes", BIOCONJUG CHEM., vol. 20, no. 11, 2009, pages 2114 - 22
  • PLATO, A.; WILLMENT, J. A.; BROWN G. D.: "C-type lectin-like receptors of the dectin-i cluster: ligands and signaling pathways", INTERNATIONAL REVIEWS OF IMMUNOLOGY, vol. 32, 2013, pages 134 - 156, XP002769383, DOI: doi:10.3109/08830185.2013.777065
  • TEMMERMAN K; NICKEL W.: "A novel flow cytometric assay to quantify interactions between proteins and membrane lipids", JOURNAL OF LIPID RESEARCH, vol. 50, no. 6, 2009, pages 1245 - 1254

Citation (search report)

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Designated extension state (EPC)

BA ME

DOCDB simple family (publication)

EP 3692984 A1 20200812; CA 3128301 A1 20200813; CN 113438945 A 20210924; EP 3920893 A1 20211215; JP 2022519707 A 20220324; US 2022152149 A1 20220519; WO 2020161247 A1 20200813

DOCDB simple family (application)

EP 19156258 A 20190208; CA 3128301 A 20200206; CN 202080013220 A 20200206; EP 2020053007 W 20200206; EP 20702808 A 20200206; JP 2021546243 A 20200206; US 202017429532 A 20200206