EP 3694593 A4 20210721 - TREATING DEMENTIA WITH VISUAL STIMULATION TO SYNCH GAMMA OSCILLATIONS IN BRAIN
Title (en)
TREATING DEMENTIA WITH VISUAL STIMULATION TO SYNCH GAMMA OSCILLATIONS IN BRAIN
Title (de)
BEHANDLUNG VON DEMENZ MIT VISUELLER STIMULATION ZUR SYNCHRONISATION VON GAMMA-SCHWINGUNGEN IM GEHIRN
Title (fr)
TRAITEMENT DE LA DÉMENCE PAR STIMULATION VISUELLE POUR INDUIRE DES OSCILLATIONS GAMA SYNCHRONISÉES DANS LE CERVEAU
Publication
Application
Priority
- US 201762570250 P 20171010
- US 201762570929 P 20171011
- US 2018051785 W 20180919
- US 2018055258 W 20181010
Abstract (en)
[origin: WO2019075094A1] Devices, systems, and methods for treating dementia or Alzheimer's disease in a subject in need thereof. In one example, chronic visual stimuli having a frequency of about 30Hz to about 50 Hz, and more specifically about 40 Hz, are non-invasively delivered to the subject to entrain gamma oscillations in multiple brain regions of the subject, including the prefrontal cortex (PFC) and the hippocampus. The entrained gamma oscillations modulate neuronal activity across multiple brain regions (e.g., facilitate functional binding of neural networks at low gamma frequencies) to induce various neuroprotective effects (e.g., amelioration of amyloid plaques and tau hyper-phosphorylation) and reduce neurodegeneration. Neuronal activity mediated by the chronic visual stimuli reduces an immune response in microglia and ameliorates aberrantly modified genes and proteins involved in membrane trafficking, intracellular transport, synaptic function, neuroinflammation and DNA damage response. Behavior modification including enhanced learning and memory is observed.
IPC 8 full level
A61H 23/00 (2006.01); A61M 21/00 (2006.01); A61N 5/06 (2006.01)
CPC (source: EP KR US)
A61M 21/00 (2013.01 - EP KR); A61N 5/0618 (2013.01 - EP KR US); A61N 5/0622 (2013.01 - EP KR US); A61M 2021/0022 (2013.01 - EP US); A61M 2021/0027 (2013.01 - EP US); A61M 2021/0044 (2013.01 - EP KR); A61M 2210/0693 (2013.01 - KR US); A61N 5/062 (2013.01 - EP US); A61N 2005/0626 (2013.01 - KR US); A61N 2005/063 (2013.01 - EP US); A61N 2005/0647 (2013.01 - EP US); A61N 2005/0648 (2013.01 - KR); A61N 2005/0651 (2013.01 - EP KR US); A61N 2005/0667 (2013.01 - EP US)
Citation (search report)
- [XY] IT RM20090027 A1 20100727 - ROCCO ALAIN
- [Y] WO 2015149170 A1 20151008 - FUNCTIONAL NEUROMODULATION INC [CA]
- [X] WO 2015066679 A2 20150507 - METZGER STEVEN [US]
- [X] US 2017143934 A1 20170525 - TSAI LI-HUEI [US], et al
- [A] WO 2008147958 A1 20081204 - UNIV JEFFERSON [US], et al
- [A] US 9272118 B1 20160301 - ACTON GEORGE [US]
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2019075094 A1 20190418; AU 2018347366 A1 20200423; AU 2018347366 B2 20220915; AU 2022271389 A1 20221215; CA 3078739 A1 20190418; CN 111655319 A 20200911; EP 3694593 A1 20200819; EP 3694593 A4 20210721; JP 2020536643 A 20201217; KR 20200086277 A 20200716; KR 20230015501 A 20230131
DOCDB simple family (application)
US 2018055258 W 20181010; AU 2018347366 A 20181010; AU 2022271389 A 20221115; CA 3078739 A 20181010; CN 201880077874 A 20181010; EP 18866752 A 20181010; JP 2020520207 A 20181010; KR 20207013291 A 20181010; KR 20237001501 A 20181010