EP 3694872 A4 20210630 - T CELL RECEPTORS FOR IMMUNOTHERAPY
Title (en)
T CELL RECEPTORS FOR IMMUNOTHERAPY
Title (de)
T-ZELLREZEPTOREN FÜR DIE IMMUNTHERAPIE
Title (fr)
COMPOSITIONS DE LYMPHOCYTES T POUR L'IMMUNOTHÉRAPIE
Publication
Application
Priority
- US 201762571447 P 20171012
- US 2018055691 W 20181012
Abstract (en)
[origin: WO2019075385A1] Provided are T cell receptors (TCR) and TCR variable regions that can selectively bind SLC45A2. The TCR may be utilized in various therapies, such as autologous cell transplantation, to treat a cancer, such as a cutaneous melanoma, uveal melanoma, a mucosal melanoma, or a metastatic melanoma. Methods for expanding a population of T cells that target SLC45A2 are also provided.
IPC 8 full level
C07K 14/725 (2006.01); C12N 5/10 (2006.01); C12N 15/12 (2006.01)
CPC (source: EP KR US)
A61K 31/675 (2013.01 - US); A61K 31/7076 (2013.01 - US); A61K 39/4611 (2023.05 - EP KR US); A61K 39/4615 (2023.05 - EP KR US); A61K 39/4622 (2023.05 - EP KR US); A61K 39/4632 (2023.05 - EP KR US); A61K 39/46449 (2023.05 - EP KR US); A61K 2239/57 (2023.05 - US); C07K 14/435 (2013.01 - EP); C07K 14/7051 (2013.01 - EP KR US); C12N 5/0636 (2013.01 - EP KR US); C12N 5/0637 (2013.01 - EP KR US); C12N 15/86 (2013.01 - US); A61K 2239/57 (2023.05 - EP KR); C07K 14/70539 (2013.01 - US); C12N 2510/00 (2013.01 - KR)
Citation (search report)
- [I] WO 2017096304 A1 20170608 - UNIV TEXAS [US]
- [A] WO 2017059084 A1 20170406 - IREPERTOIRE INC [US]
- [I] PARK JUNGSUN ET AL: "SLC45A2: A Melanoma Antigen with High Tumor Selectivity and Reduced Potential for Autoimmune Toxicity", CANCER IMMUNOLOGY RESEARCH, vol. 5, no. 8, 1 August 2017 (2017-08-01), US, pages 618 - 629, XP055804906, ISSN: 2326-6066, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087543/pdf/nihms980623.pdf> DOI: 10.1158/2326-6066.CIR-17-0051
- [A] DUNN STEVEN M ET AL: "Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity", PROTEIN SCIENCE, WILEY, US, vol. 15, no. 4, 1 April 2006 (2006-04-01), pages 710 - 721, XP002465974, ISSN: 0961-8368, DOI: 10.1110/PS.051936406
- See also references of WO 2019075385A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2019075385 A1 20190418; AU 2018346957 A1 20200423; AU 2018346957 B2 20240801; CA 3081336 A1 20190418; CN 111433222 A 20200717; EP 3694872 A1 20200819; EP 3694872 A4 20210630; JP 2021500878 A 20210114; KR 20200064126 A 20200605; US 2020237820 A1 20200730
DOCDB simple family (application)
US 2018055691 W 20181012; AU 2018346957 A 20181012; CA 3081336 A 20181012; CN 201880075955 A 20181012; EP 18867027 A 20181012; JP 2020520494 A 20181012; KR 20207013231 A 20181012; US 201816652932 A 20181012