Global Patent Index - EP 3696187 A4

EP 3696187 A4 20211208 - SYNTHETIC PEPTIDE SP4 AND USE THEREOF

Title (en)

SYNTHETIC PEPTIDE SP4 AND USE THEREOF

Title (de)

SYNTHETISCHES PEPTID SP4 UND VERWENDUNG DAVON

Title (fr)

PEPTIDE SYNTHÉTIQUE SP4 ET SON UTILISATION

Publication

EP 3696187 A4 20211208 (EN)

Application

EP 18925139 A 20181012

Priority

  • CN 201810739279 A 20180706
  • CN 2018109931 W 20181012

Abstract (en)

[origin: EP3696187A1] Disclosed is a synthetic peptide sp4 with an amino acid sequence shown in SEQ ID No.1. As the sole effective ingredient in the antitumor efficacy test, it has a significant inhibitory effect on both the tumor volume and tumor weight of human osteosarcoma MG-63 in nude mice and has a significant dose-effect and time-effect relationship. There is no difference between the relative tumor growth rate T/C (%) of sp4 and that of the positive control group of Paclitaxel. The safety of sp4 is that its maximal tolerated dose for intravenous administration is 700mg/kgBW. Sp4 has clear targets of pharmacological effects, while having efficacy in vivo, it also has an inhibitory effect on tumor telomerase, has a arrest on G1 phase of the tumor cell cycle, and inhibits the high expressions of tumor PD-L1 and CD47. The present disclosure relates to multiple uses of sp4, especially in the preparation of a class of antitumor drugs.

IPC 8 full level

C07K 7/08 (2006.01); A61K 38/10 (2006.01); A61P 35/00 (2006.01); C07K 1/04 (2006.01); C07K 14/415 (2006.01)

CPC (source: CN EP US)

A61P 35/00 (2018.01 - CN EP US); C07K 7/08 (2013.01 - CN EP US); A61K 38/00 (2013.01 - CN EP US)

Citation (search report)

  • [A] US 2010111988 A1 20100506 - SHOU CHENGCHAO [CN], et al
  • [A] CN 103819554 A 20140528 - UNIV CHINA PHARMA
  • [XY] GAO BIN ET AL: "Mesobuthus Venom-Derived Antimicrobial Peptides Possess Intrinsic Multifunctionality and Differential Potential as Drugs", FRONTIERS IN MICROBIOLOGY, vol. 9, 27 February 2018 (2018-02-27), XP055855727, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863496/pdf/fmicb-09-00320.pdf> [retrieved on 20180227], DOI: 10.3389/fmicb.2018.00320
  • [X] ZENG XIAN-CHUN ET AL: "Identification and functional characterization of novel scorpion venom peptides with no disulfide bridge from Buthus martensii Karsch", PEPTIDES, vol. 25, no. 2, 1 February 2004 (2004-02-01), AMSTERDAM, NL, pages 143 - 150, XP055855373, ISSN: 0196-9781, [retrieved on 20040401], DOI: 10.1016/j.peptides.2003.12.003
  • [Y] RADY ISLAM ET AL: "Melittin, a major peptide component of bee venom, and its conjugates in cancer therapy", CANCER LETTERS, NEW YORK, NY, US, vol. 402, 20 May 2017 (2017-05-20), pages 16 - 31, XP085126295, ISSN: 0304-3835, [retrieved on 20170520], DOI: 10.1016/J.CANLET.2017.05.010
  • See also references of WO 2020006922A1

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

EP 3696187 A1 20200819; EP 3696187 A4 20211208; CA 3079766 A1 20200109; CA 3079766 C 20230808; CN 109134616 A 20190104; CN 109134616 B 20200424; JP 2021504456 A 20210215; JP 6934217 B2 20210915; US 11939399 B2 20240326; US 2021179664 A1 20210617; US 2022332761 A1 20221020; WO 2020006922 A1 20200109

DOCDB simple family (application)

EP 18925139 A 20181012; CA 3079766 A 20181012; CN 2018109931 W 20181012; CN 201811191667 A 20181012; JP 2020545841 A 20181012; US 201816762470 A 20181012; US 202217656347 A 20220324