EP 3704153 A2 20200909 - BISPECIFIC ANTIBODIES BINDING ALK-1 AND BMPR-2
Title (en)
BISPECIFIC ANTIBODIES BINDING ALK-1 AND BMPR-2
Title (de)
AN ALK-1 UND BMPR-2 BINDENDE BISPEZIFISCHE ANTIKÖRPER
Title (fr)
ANTICORPS BISPÉCIFIQUES SE LIANT À ALK-1 ET BMPR-2
Publication
Application
Priority
- EP 17199746 A 20171102
- EP 17200666 A 20171108
- EP 2018079333 W 20181025
Abstract (en)
[origin: WO2019086331A2] Bispecific antibodies binding ALK-1 and BMPR-2 The present invention relates to bispecific antibodies binding human ALK-1 and human BMPR-2. Also provided are BsABs which are agonists of ALK-1/BMPR-2 signaling, and BsABs which do not trigger osteogenic signaling. Furthermore, the invention relates to pharmaceutical uses of the BsABs, in particular for the treatment of pulmonary hypertension. Also provided are methods to screen for BsABs for use in the therapy, e.g.of pulmonary hypertension.
IPC 8 full level
C07K 16/28 (2006.01); A61K 39/00 (2006.01); A61P 9/12 (2006.01)
CPC (source: EP IL KR US)
A61P 7/00 (2018.01 - KR); A61P 11/00 (2018.01 - KR); C07K 16/2863 (2013.01 - EP IL KR US); G01N 33/6854 (2013.01 - US); A61K 2039/505 (2013.01 - KR); C07K 2317/31 (2013.01 - EP IL KR US); C07K 2317/622 (2013.01 - EP IL KR US); C07K 2317/75 (2013.01 - EP IL KR US); C07K 2317/92 (2013.01 - US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2019086331 A2 20190509; WO 2019086331 A3 20190613; AU 2018358804 A1 20200409; CA 3081152 A1 20190509; CA 3185525 A1 20190509; CN 111344306 A 20200626; EP 3704153 A2 20200909; IL 274121 A 20200630; JP 2021501759 A 20210121; JP 7433224 B2 20240219; KR 20200074201 A 20200624; MX 2020004561 A 20200813; RU 2020117439 A 20211202; SG 11202002590V A 20200429; TW 201932484 A 20190816; US 11292846 B2 20220405; US 2020332013 A1 20201022; US 2022185901 A1 20220616
DOCDB simple family (application)
EP 2018079333 W 20181025; AU 2018358804 A 20181025; CA 3081152 A 20181025; CA 3185525 A 20181025; CN 201880070156 A 20181025; EP 18796610 A 20181025; IL 27412120 A 20200421; JP 2020524299 A 20181025; KR 20207015174 A 20181025; MX 2020004561 A 20181025; RU 2020117439 A 20181025; SG 11202002590V A 20181025; TW 107138502 A 20181031; US 201816760704 A 20181025; US 202217681573 A 20220225