EP 3710061 A1 20200923 - POLYMER PRODRUGS AND SUBCUTANEOUS AND/OR INTRAMUSCULAR ADMINISTRATION THEREOF
Title (en)
POLYMER PRODRUGS AND SUBCUTANEOUS AND/OR INTRAMUSCULAR ADMINISTRATION THEREOF
Title (de)
POLYMER-PRODRUGS UND SUBKUTANE UND / ODER INTRAMUSKULÄRE VERABREICHUNG DAVON
Title (fr)
PRODROGUES POLYMÈRES ET LEUR ADMINISTRATION SOUS-CUTANEE ET/OU INTRAMUSCULAIRE
Publication
Application
Priority
- FR 1760869 A 20171117
- FR 1760868 A 20171117
- EP 2018081636 W 20181116
Abstract (en)
[origin: WO2019097025A1] The invention relates to novel prodrugs of active molecules. These prodrugs enable in particular the subcutaneous or intramuscular administration of active molecules of which the subcutaneous or intramuscular administration is problematic or impossible, in particular because of the toxicity at the injection site. The prodrugs of the invention comprise an active ingredient covalently bonded with a polymer chain, preferably a hydrophilic and/or heat-sensitive polymer chain. The invention relates in particular to polymer prodrugs comprising a polymer chain at least partly formed of monomer of acrylamide or a derivative thereof, said polymer comprising a proximal portion and a terminal portion; a first pharmaceutically active molecule covalently coupled to the proximal portion of the polymer; and optionally a second pharmaceutically active molecule covalently coupled to the terminal portion of the polymer.
IPC 8 full level
A61K 47/58 (2017.01); A61P 35/00 (2006.01)
CPC (source: EP KR US)
A61K 9/0019 (2013.01 - KR US); A61K 9/0021 (2013.01 - KR); A61K 31/337 (2013.01 - KR); A61K 47/58 (2017.07 - EP KR US); A61K 49/0041 (2013.01 - US); A61K 49/0054 (2013.01 - US); A61P 35/00 (2017.12 - EP KR); C08F 220/56 (2013.01 - US); C08F 293/005 (2013.01 - US); C08F 2438/03 (2013.01 - US)
Citation (search report)
See references of WO 2019097025A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2019097025 A1 20190523; CA 3082835 A1 20190523; CN 111615405 A 20200901; CN 111615405 B 20231128; EP 3710061 A1 20200923; JP 2021503510 A 20210212; JP 7341152 B2 20230908; KR 20200122294 A 20201027; US 2020353090 A1 20201112
DOCDB simple family (application)
EP 2018081636 W 20181116; CA 3082835 A 20181116; CN 201880074743 A 20181116; EP 18800227 A 20181116; JP 2020545449 A 20181116; KR 20207017475 A 20181116; US 201816764492 A 20181116