Global Patent Index - EP 3719033 A1

EP 3719033 A1 20201007 - STABILIZED MHC I

Title (en)

STABILIZED MHC I

Title (de)

STABILISIERTES MHC I

Title (fr)

MHC I STABILISÉ

Publication

EP 3719033 A1 20201007 (EN)

Application

EP 19166923 A 20190402

Priority

EP 19166923 A 20190402

Abstract (en)

The present invention relates to modified MHC I molecules that can be expressed in cell culture and are more stable than natural MHC I molecules. Further, the invention relates to analytical processes using the modified MHC I molecules, e.g. for determination of antibodies in a serum sample directed against these MHC I molecules. The invention provides MHC I which has at least one covalent bond formed between an Cystein in the alpha chain and an amino acid residue of the β2-microglobulin.

IPC 8 full level

C07K 14/74 (2006.01)

CPC (source: EP US)

C07K 14/70539 (2013.01 - EP US)

Citation (applicant)

  • US 6682741 B1 20040127 - RIBAUDO RANDALL K [US], et al
  • SHIELDS ET AL., THE JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, pages 28010 - 28018

Citation (search report)

  • [XYI] WO 2017201131 A1 20171123 - ALBERT EINSTEIN COLLEGE MEDICINE INC [US]
  • [XYI] WO 2019051091 A1 20190314 - CUE BIOPHARMA INC [US]
  • [A] WO 9911775 A1 19990311 - HARVARD COLLEGE [US], et al
  • [Y] WO 2011101681 A2 20110825 - UNI I OSLO [NO], et al
  • [Y] SHIELDS ET AL: "The effect of human B2-microglobulin on major histocompatibility complex I peptide loading and the engineering of a high affinity variant", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 273, no. 43, 23 October 1998 (1998-10-23), pages 28010 - 28018, XP002115505, ISSN: 0021-9258, DOI: 10.1074/JBC.273.43.28010
  • [A] Z. HEIN ET AL: "Peptide-independent stabilization of MHC class I molecules breaches cellular quality control", JOURNAL OF CELL SCIENCE, vol. 127, no. 13, 7 May 2014 (2014-05-07), pages 2885 - 2897, XP055530836, ISSN: 0021-9533, DOI: 10.1242/jcs.145334

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Designated extension state (EPC)

BA ME

DOCDB simple family (publication)

EP 3719033 A1 20201007; EP 3947438 A1 20220209; US 2022153808 A1 20220519; WO 2020201467 A1 20201008

DOCDB simple family (application)

EP 19166923 A 20190402; EP 2020059472 W 20200402; EP 20715384 A 20200402; US 202017439485 A 20200402