EP 3724166 A1 20201021 - PROCESS FOR THE MANUFACTURE OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS
Title (en)
PROCESS FOR THE MANUFACTURE OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS
Title (de)
VERFAHREN ZUR HERSTELLUNG VON INHIBITOREN VON 11-BETA-HYDROXYSTEROID-DEHYDROGENASE TYP 1
Title (fr)
PROCÉDÉ DE FABRICATION D'INHIBITEURS DE 11-BÊTA-HYDROXYSTÉROÏDE DÉSHYDROGÉNASE DE TYPE 1
Publication
Application
Priority
- EP 17206574 A 20171212
- EP 18171625 A 20180509
- EP 2018084367 W 20181211
Abstract (en)
[origin: WO2019115531A1] The present invention is directed to a process for the manufacture of a compound of formula (I) wherein Y is CHR7, CR7R8 or O, n is 0, 1 or 2, R1 and R2 are independently of each other selected from the group consisting of H, F, Cl, methyl and ethyl, and R3, R4, R5, R6, R7 and, R8 are independently of each other selected from H or C1-C6-alkyl. The compounds of formula (I) are 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors and can be used to reduce Cortisol levels in keratinocytes and to improve dermal collagen content in human skin after exposure to cortisone and UV.
IPC 8 full level
C07D 223/04 (2006.01)
CPC (source: EP)
C07D 223/04 (2013.01)
Citation (search report)
See references of WO 2019115531A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2019115531 A1 20190620; CN 111433189 A 20200717; EP 3724166 A1 20201021
DOCDB simple family (application)
EP 2018084367 W 20181211; CN 201880079453 A 20181211; EP 18829243 A 20181211