EP 3724221 A1 20201021 - VARIANTS WITH FC FRAGMENT HAVING AN INCREASED AFFINITY FOR FCRN AND AN INCREASED AFFINITY FOR AT LEAST ONE RECEPTOR OF THE FC FRAGMENT
Title (en)
VARIANTS WITH FC FRAGMENT HAVING AN INCREASED AFFINITY FOR FCRN AND AN INCREASED AFFINITY FOR AT LEAST ONE RECEPTOR OF THE FC FRAGMENT
Title (de)
VARIANTEN MIT FC-FRAGMENT MIT ERHÖHTER AFFINITÄT FÜR FCRN UND ERHÖHTER AFFINITÄT FÜR MINDESTENS EINEN REZEPTOR DES FC-FRAGMENTS
Title (fr)
VARIANTS AVEC FRAGMENT FC AYANT UNE AFFINITÉ AUGMENTÉE POUR FCRN ET UNE AFFINITÉ AUGMENTÉE POUR AU MOINS UN RÉCEPTEUR DU FRAGMENT FC
Publication
Application
Priority
- FR 1762217 A 20171215
- EP 2018084970 W 20181214
Abstract (en)
[origin: WO2019115773A1] The present invention concerns a variant of a parent polypeptide comprising an Fc fragment, said variant having an increased affinity for the FcRn receptor, and an increased affinity for at least one receptor of the Fc fragment (FcR) chosen from the FcγRI (CD64), FcγRIIIa (CD16a) and FcγRIIa (CD32a) receptors, relative to that of the parent polypeptide, characterised in that it comprises: (i) the four mutations 334N, 352S, 378V and 397M; and (ii) at least one mutation chosen from 434Y, 434S, 226G, P228L, P228R, 230S, 230T, 230L, 241L, 264E, 307P, 315D, 330V, 362R, 389T and 389K; the numbering being that of the EU index or the Kabat equivalent.
IPC 8 full level
C07K 16/04 (2006.01)
CPC (source: EP KR US)
A61K 39/395 (2013.01 - EP); A61P 7/00 (2018.01 - KR US); A61P 19/02 (2018.01 - US); A61P 25/00 (2018.01 - KR); A61P 27/00 (2018.01 - KR); A61P 37/06 (2018.01 - US); C07K 16/04 (2013.01 - EP KR US); C07K 16/18 (2013.01 - EP); C07K 16/283 (2013.01 - KR US); C12P 21/00 (2013.01 - EP); A61K 2039/505 (2013.01 - EP US); C07K 2317/12 (2013.01 - US); C07K 2317/52 (2013.01 - EP KR US); C07K 2317/732 (2013.01 - EP KR); C07K 2317/734 (2013.01 - EP KR); C07K 2317/92 (2013.01 - KR US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2019115773 A1 20190620; AU 2018382593 A1 20200625; BR 112020012016 A2 20201124; CA 3084602 A1 20190620; CN 111601821 A 20200828; CN 111601821 B 20240614; EP 3724221 A1 20201021; FR 3075200 A1 20190621; FR 3075200 B1 20221223; JP 2021508444 A 20210311; JP 2023134604 A 20230927; KR 20200098512 A 20200820; MX 2020006013 A 20200817; RU 2020119543 A 20211213; US 2021214434 A1 20210715
DOCDB simple family (application)
EP 2018084970 W 20181214; AU 2018382593 A 20181214; BR 112020012016 A 20181214; CA 3084602 A 20181214; CN 201880080414 A 20181214; EP 18829783 A 20181214; FR 1762217 A 20171215; JP 2020532813 A 20181214; JP 2023113380 A 20230711; KR 20207016305 A 20181214; MX 2020006013 A 20181214; RU 2020119543 A 20181214; US 201816772244 A 20181214