Global Patent Index - EP 3757226 A3

EP 3757226 A3 20210505 - A MULTI-PROTEIN BIOMARKER ASSAY FOR BRAIN INJURY DETECTION AND OUTCOME

Title (en)

A MULTI-PROTEIN BIOMARKER ASSAY FOR BRAIN INJURY DETECTION AND OUTCOME

Title (de)

MULTIPROTEIN-BIOMARKERTEST FÜR DEN NACHWEIS VON HIRNLÄSIONEN UND ERGEBNIS

Title (fr)

DOSAGE DE BIOMARQUEURS MULTIPROTÉINIQUES POUR LA DÉTECTION ET L'ISSUE DE LÉSIONS CÉRÉBRALES

Publication

EP 3757226 A3 20210505 (EN)

Application

EP 20191259 A 20140717

Priority

  • US 201361847213 P 20130717
  • EP 14826786 A 20140717
  • US 2014046986 W 20140717

Abstract (en)

The present invention relates to the field of brain injuries. More specifically, the present invention provides methods and compositions useful in the diagnosis/prognosis/assessment of brain injuries. In a specific embodiment, a method for identifying which patients with traumatic brain injury (TBI) require a head computerized tomography (CT) scan for diagnosing acute intracranial pathology comprises the steps of (a) obtaining or collecting a sample from the patient; (b) measuring the levels of one or more biomarkers in the blood sample obtained from the patient, wherein the biomarkers comprise glial fibrillary acidic protein (GFAP), S 100B, metallothionein 3 (MT3), neuron specific enolase (NSE) and intracellular adhesion molecule 5 (ICAM5); and (c) identifying the patient as requiring or not requiring a head CT scan based on the measured levels of one or more of biomarkers comprising GFAP, S100B, MT3, NSE and ICAM5.

IPC 8 full level

C12Q 1/68 (2018.01)

CPC (source: EP US)

C12Q 1/6883 (2013.01 - EP US); G01N 33/6893 (2013.01 - EP US); C12Q 2600/158 (2013.01 - EP US); G01N 2333/4727 (2013.01 - US); G01N 2333/70525 (2013.01 - US); G01N 2333/825 (2013.01 - US); G01N 2333/988 (2013.01 - US); G01N 2800/28 (2013.01 - US); G01N 2800/2871 (2013.01 - EP US)

Citation (search report)

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Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2015009907 A1 20150122; EP 3022322 A1 20160525; EP 3022322 A4 20170517; EP 3757226 A2 20201230; EP 3757226 A3 20210505; IL 243393 A0 20160331; JP 2016533499 A 20161027; JP 2020034567 A 20200305; JP 2022023999 A 20220208; JP 6611710 B2 20191127; JP 6980291 B2 20211215; US 10534003 B2 20200114; US 11499982 B2 20221115; US 2016178643 A1 20160623; US 2020116739 A1 20200416; US 2023077876 A1 20230316

DOCDB simple family (application)

US 2014046986 W 20140717; EP 14826786 A 20140717; EP 20191259 A 20140717; IL 24339315 A 20151228; JP 2016527092 A 20140717; JP 2019195925 A 20191029; JP 2021181686 A 20211108; US 201414905312 A 20140717; US 201916713425 A 20191213; US 202217982769 A 20221108