EP 3765491 C0 20240403 - INDUCIBLE T CELL RECEPTORS AND USES THEREOF
Title (en)
INDUCIBLE T CELL RECEPTORS AND USES THEREOF
Title (de)
INDUZIERBARE T-ZELL-REZEPTOREN UND VERWENDUNGEN DAVON
Title (fr)
RÉCEPTEURS DE LYMPHOCYTE T INDUCTIBLES ET UTILISATIONS ASSOCIÉES
Publication
Application
Priority
- EP 18161766 A 20180314
- EP 2019056228 W 20190313
Abstract (en)
[origin: WO2019175209A1] The present invention relates to (nucleic acids encoding) inducible T cell receptors (iTCRs), compositions and kits, vectors and host cells comprising such (nucleic acids encoding) inducible T cell receptors, uses thereof in preparing inducible T cell receptors and host cells comprising such T cell receptors, methods for preparing such inducible T cell receptors and for dimerizing T cell receptors, as well as medical uses of such compounds and pharmaceutical compositions comprising them, particularly for treating cancer. The present invention relates to combinations comprising one or more nucleic acid molecules, said one or more nucleic acid molecules comprising a nucleic acid sequence A encoding for a TCR alpha chain linked to a dimerization domain, and a nucleic acid sequence B encoding for a TCR beta chain linked to a dimerization domain, as well as proteins encoded by such nucleic acid molecules and corresponding uses and methods.
IPC 8 full level
C07K 14/725 (2006.01); A61K 31/138 (2006.01)
CPC (source: EP US)
A61K 31/138 (2013.01 - US); A61K 35/17 (2013.01 - US); A61K 39/4611 (2023.05 - EP); A61K 39/4632 (2023.05 - EP); A61K 39/464488 (2023.05 - EP); A61K 39/464489 (2023.05 - EP); C07K 14/7051 (2013.01 - EP US); C12N 15/86 (2013.01 - US); C12N 2799/027 (2013.01 - US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Participating member state (EPC – UP)
AT BE BG DE DK EE FI FR IT LT LU LV MT NL PT SE SI
DOCDB simple family (publication)
WO 2019175209 A1 20190919; CN 112119087 A 20201222; EP 3765491 A1 20210120; EP 3765491 B1 20240403; EP 3765491 C0 20240403; JP 2021515574 A 20210624; JP 7412006 B2 20240112; TW 202003540 A 20200116; US 2021038647 A1 20210211
DOCDB simple family (application)
EP 2019056228 W 20190313; CN 201980031948 A 20190313; EP 19716076 A 20190313; JP 2020548789 A 20190313; TW 108108646 A 20190314; US 201916980345 A 20190313