EP 3770181 A4 20211117 - METHOD FOR PREPARING HYALURONIC ACID HYDROGEL MIROPARTICLES AND USE THEREOF IN REPAIRING ARTICULAR CARTILAGE DEFECTS
Title (en)
METHOD FOR PREPARING HYALURONIC ACID HYDROGEL MIROPARTICLES AND USE THEREOF IN REPAIRING ARTICULAR CARTILAGE DEFECTS
Title (de)
VERFAHREN ZUR HERSTELLUNG VON HYALURONSÄUREHYDROGEL-MIKROPARTIKELN UND DEREN VERWENDUNG ZUR REPARATUR VON GELENKKNORPELDEFEKTEN
Title (fr)
PROCÉDÉ DE PRÉPARATION DE MICROPARTICULES D'HYDROGEL D'ACIDE HYALURONIQUE ET LEUR UTILISATION DANS LA RÉPARATION DE DÉFAUTS DU CARTILAGE ARTICULAIRE
Publication
Application
Priority
CN 2018080135 W 20180323
Abstract (en)
[origin: EP3770181A1] A method for preparing hyaluronic acid hydrogel microparticles and a use thereof in repairing articular cartilage defects, the method for preparing hyaluronic acid hydrogel microparticles includes: (a) reacting hyaluronic acid with methacrylic anhydride to synthesize a methacrylated hyaluronic acid conjugate; (b) mixing the methacrylated hyaluronic acid conjugate with a photoinitiator, and irradiating ultraviolet light to carry out a photopolymerization reaction so as to obtain a hyaluronic acid hydrogel; and (c) passing the hyaluronic acid hydrogel through a sieve to obtain hyaluronic acid hydrogel microparticles.
IPC 8 full level
C08B 37/08 (2006.01); A61L 27/52 (2006.01); C08F 2/48 (2006.01); C08F 299/00 (2006.01); C08J 3/075 (2006.01); C08J 3/24 (2006.01); C08J 3/28 (2006.01); C08L 5/08 (2006.01)
CPC (source: EP US)
A61L 27/20 (2013.01 - EP US); A61L 27/52 (2013.01 - EP US); C08B 37/0072 (2013.01 - EP); C08F 299/028 (2013.01 - EP); C08J 3/075 (2013.01 - EP US); C08J 3/12 (2013.01 - EP); C08J 3/24 (2013.01 - EP); C08J 3/28 (2013.01 - EP US); C08L 5/08 (2013.01 - EP); A61L 2430/06 (2013.01 - EP US); C08F 2/50 (2013.01 - EP); C08J 2305/08 (2013.01 - EP US)
C-Set (source: EP)
Citation (search report)
- [Y] US 2009226499 A1 20090910 - WISNIEWSKI HANS-GEORG [US], et al
- [X] XIAN XU ET AL: "Hyaluronic acid-based hydrogels: from a natural polysaccharide to complex networks", SOFT MATTER (PRINT), vol. 8, no. 12, 1 January 2012 (2012-01-01), GB, pages 3280, XP055363242, ISSN: 1744-683X, DOI: 10.1039/c2sm06463d
- [Y] XIA CHEN ET AL: "Photo-crosslinked HAMA hydrogel with cordycepin encapsulated chitosan microspheres for osteoarthritis treatment", ONCOTARGET, vol. 8, no. 2, 10 January 2017 (2017-01-10), United States, pages 2835 - 2849, XP055848904, ISSN: 1949-2553, DOI: 10.18632/oncotarget.13748
- [Y] KIM JIN-TAE ET AL: "Tissue response to implants of hyaluronic acid hydrogel prepared by microbeads", TISSUE ENGINEERING AND REGENERATIVE MEDICINE - JO'JIG GONGHAG GWA JAESAENG UIHAG, vol. 11, no. 1, 1 February 2014 (2014-02-01), KI, pages 32 - 38, XP055849471, ISSN: 1738-2696, Retrieved from the Internet <URL:https://link.springer.com/content/pdf/10.1007/s13770-013-1106-9.pdf> DOI: 10.1007/s13770-013-1106-9
- See also references of WO 2019178825A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
EP 3770181 A1 20210127; EP 3770181 A4 20211117; JP 2021517177 A 20210715; JP 2022130665 A 20220906; JP 7471006 B2 20240419; US 2021015967 A1 20210121; WO 2019178825 A1 20190926
DOCDB simple family (application)
EP 18910697 A 20180323; CN 2018080135 W 20180323; JP 2020545524 A 20180323; JP 2022107117 A 20220701; US 201816982597 A 20180323