EP 3774772 A1 20210217 - CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME
Title (en)
CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME
Title (de)
CEREBLONLIGANDEN UND BIFUNKTIONALE VERBINDUNGEN DAMIT
Title (fr)
LIGANDS DE CÉRÉBLON ET COMPOSÉS BIFONCTIONNELS LES CONTENANT
Publication
Application
Priority
- US 201815953108 A 20180413
- US 2019026570 W 20190409
Abstract (en)
[origin: WO2019199816A1] The description relates to cereblon E3 ligase binding compounds, including bifunctional compounds comprising the same, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present disclosure. In particular, the description provides compounds, which contain on one end a ligand which binds to the cereblon E3 ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. Compounds can be synthesized that exhibit a broad range of pharmacological activities consistent with the degradation/inhibition of targeted polypeptides of nearly any type.
IPC 8 full level
C07D 401/14 (2006.01); A61K 31/438 (2006.01); A61K 31/496 (2006.01); A61K 31/519 (2006.01); A61K 31/53 (2006.01); A61P 35/00 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 495/14 (2006.01)
CPC (source: EP IL KR)
A61K 31/437 (2013.01 - KR); A61K 31/4439 (2013.01 - KR); A61K 31/444 (2013.01 - KR); A61K 31/4985 (2013.01 - KR); A61K 31/517 (2013.01 - KR); A61K 31/519 (2013.01 - KR); A61K 31/55 (2013.01 - KR); A61K 31/5517 (2013.01 - KR); A61K 45/06 (2013.01 - KR); A61P 35/00 (2018.01 - EP IL KR); C07D 401/04 (2013.01 - KR); C07D 401/14 (2013.01 - EP IL); C07D 471/04 (2013.01 - EP IL KR); C07D 487/04 (2013.01 - EP IL KR); C07D 495/14 (2013.01 - EP IL KR); C07D 498/14 (2013.01 - KR)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2019199816 A1 20191017; AU 2019251223 A1 20201126; AU 2023248067 A1 20231102; CA 3095912 A1 20191017; CN 112262134 A 20210122; CN 112262134 B 20240524; CN 118480030 A 20240813; EP 3774772 A1 20210217; IL 277934 A 20201130; IL 302595 A 20230701; IL 310860 A 20240401; JP 2021521192 A 20210826; JP 2023175957 A 20231212; KR 20210003804 A 20210112; MX 2020010571 A 20210108; MX 2023002134 A 20230316
DOCDB simple family (application)
US 2019026570 W 20190409; AU 2019251223 A 20190409; AU 2023248067 A 20231010; CA 3095912 A 20190409; CN 201980036235 A 20190409; CN 202410558602 A 20190409; EP 19719093 A 20190409; IL 27793420 A 20201011; IL 30259523 A 20230502; IL 31086024 A 20240215; JP 2020555835 A 20190409; JP 2023174374 A 20231006; KR 20207032733 A 20190409; MX 2020010571 A 20190409; MX 2023002134 A 20201007