Global Patent Index - EP 3778882 A4

EP 3778882 A4 20210609 - RECOMBINANT ONCOLYTIC VIRUS COMPOSITION AND USE THEREOF

Title (en)

RECOMBINANT ONCOLYTIC VIRUS COMPOSITION AND USE THEREOF

Title (de)

REKOMBINANTE ONKOLYTISCHE VIRENZUSAMMENSETZUNG UND VERWENDUNGEN DAVON

Title (fr)

COMPOSITION DE VIRUS ONCOLYTIQUE RECOMBINANT ET UTILISATION ASSOCIÉE

Publication

EP 3778882 A4 20210609 (EN)

Application

EP 19784788 A 20190321

Priority

  • CN 201810331305 A 20180413
  • CN 2019078999 W 20190321

Abstract (en)

[origin: EP3778882A1] Provided is a recombinant oncolytic virus composition, comprising a first recombinant oncolytic virus and a second recombinant oncolytic virus. Both the first and second recombinant oncolytic viruses comprise a herpes simplex virus vector and an exogenous gene, the exogenous gene is encoded from one of cytokine, a monoclonal antibody having a tumor preventative and/or treatment function, tumor antigens, prodrug invertase, tumor suppressor polypeptide, antisense RNA or small RNA, wherein the exogenous genes in the first and the second recombinant oncolytic viruses are different. Also provided is an application of the recombinant oncolytic virus composition in preparation of a medicamentdrug for treating tumors.

IPC 8 full level

C12N 7/01 (2006.01); A61K 35/763 (2015.01); A61P 35/00 (2006.01); A61P 35/04 (2006.01); C12N 15/869 (2006.01)

CPC (source: CN EP US)

A61K 35/763 (2013.01 - EP US); A61K 35/768 (2013.01 - CN); A61P 35/00 (2017.12 - CN EP US); A61P 35/04 (2017.12 - EP); C07K 14/535 (2013.01 - US); C07K 14/5434 (2013.01 - US); C07K 14/55 (2013.01 - US); C07K 16/2818 (2013.01 - US); C12N 7/00 (2013.01 - EP US); C12N 15/86 (2013.01 - EP); C12N 2710/16632 (2013.01 - EP US); C12N 2710/16643 (2013.01 - EP US)

C-Set (source: CN)

A61K 35/768 + A61K 2300/00

Citation (search report)

  • [XY] WO 9907394 A1 19990218 - UNIV GEORGETOWN [US], et al
  • [XY] PARKER J N ET AL: "Enhanced inhibition of syngeneic murine tumors by combinatorial therapy with genetically engineered HSV-1 expressing CCL2 and IL-12", CANCER GENE THERAPY, vol. 12, no. 4, 1 April 2005 (2005-04-01), New York, pages 359 - 368, XP055799742, ISSN: 0929-1903, Retrieved from the Internet <URL:https://www.nature.com/articles/7700784.pdf> DOI: 10.1038/sj.cgt.7700784
  • [XY] ZHANG W ET AL: "Combination of Oncolytic Herpes Simplex Viruses Armed with Angiostatin and IL-12 Enhances Antitumor Efficacy in Human Glioblastoma Models", NEOPLASIA, vol. 15, no. 6, 1 June 2013 (2013-06-01), US, pages 591 - 599, XP055658912, ISSN: 1476-5586, DOI: 10.1593/neo.13158
  • [XY] INO Y ET AL: "Triple combination of oncolytic herpes simplex virus-1 vectors armed with interleukin-12, interleukin-18, or soluble B7-1 results in enhanced antitumor efficacy", CLINICAL CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 12, no. 2, 15 January 2006 (2006-01-15), pages 643 - 652, XP002533120, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-05-1494
  • [Y] DE GRAAF J F ET AL: "Armed oncolytic viruses: A kick-start for anti-tumor immunity", CYTOKINE & GROWTH FACTOR REVIEWS, vol. 41, 19 March 2018 (2018-03-19), GB, pages 28 - 39, XP055580278, ISSN: 1359-6101, DOI: 10.1016/j.cytogfr.2018.03.006
  • See references of WO 2019196617A1

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Designated extension state (EPC)

BA ME

DOCDB simple family (publication)

EP 3778882 A1 20210217; EP 3778882 A4 20210609; CN 108635380 A 20181012; CN 109745343 A 20190514; CN 109745343 B 20210409; TW 201945542 A 20191201; TW I704226 B 20200911; US 2021138008 A1 20210513; WO 2019196617 A1 20191017

DOCDB simple family (application)

EP 19784788 A 20190321; CN 201810331305 A 20180413; CN 2019078999 W 20190321; CN 201910216843 A 20190321; TW 108112968 A 20190412; US 201917044074 A 20190321