EP 3783026 A4 20210811 - SWITCH MOLECULE AND SWITCHABLE CHIMERIC ANTIGEN RECEPTOR
Title (en)
SWITCH MOLECULE AND SWITCHABLE CHIMERIC ANTIGEN RECEPTOR
Title (de)
SCHALTERMOLEKÜL UND UMSCHALTBARER CHIMÄRER ANTIGENREZEPTOR
Title (fr)
MOLÉCULE DE COMMUTATION ET RÉCEPTEUR ANTIGÉNIQUE CHIMÉRIQUE COMMUTABLE
Publication
Application
Priority
- KR 20180045228 A 20180418
- KR 2019004720 W 20190418
Abstract (en)
[origin: EP3783026A1] The present invention relates to a switch molecule for activating a chimeric antigen receptor effector cell, to a polypeptide or fusion protein binding thereto, and to a chimeric antigen receptor. (i) When a switch molecule of the present invention is used, in order to improve safety of a CAR-T cell, if severe toxicity appears, a switch molecule lacking a targeting moiety can be injected to adjust activation of the CAR-T cell. (ii) When an antigen is mutated, or in order to cure various carcinomas, instead of an existing switch molecule, a switch molecule targeting a new antigen generated due to the mutation or a switch molecule targeting a different tumor associated antigen (TAA) can be injected into a patient to cure cancer more effectively.
IPC 8 full level
C07K 16/28 (2006.01); A61K 35/17 (2015.01); A61K 39/395 (2006.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01); C07K 16/32 (2006.01); C07K 16/46 (2006.01); C12N 5/0783 (2010.01)
CPC (source: EP KR US)
A61K 39/395 (2013.01 - KR); A61K 39/4611 (2023.05 - EP KR); A61K 39/4631 (2023.05 - EP KR); A61K 39/464406 (2023.05 - EP KR); A61K 39/464412 (2023.05 - EP KR); C07K 14/7051 (2013.01 - EP KR); C07K 16/28 (2013.01 - KR US); C07K 16/2803 (2013.01 - EP US); C07K 16/32 (2013.01 - EP KR US); C07K 16/46 (2013.01 - EP); C12N 5/0636 (2013.01 - EP KR); A61K 39/395 (2013.01 - EP); A61K 2239/23 (2023.05 - EP KR); A61K 2300/00 (2013.01 - KR); C07K 2317/24 (2013.01 - EP); C07K 2317/31 (2013.01 - EP); C07K 2317/56 (2013.01 - EP); C07K 2317/622 (2013.01 - EP US); C07K 2318/20 (2013.01 - EP US); C07K 2319/00 (2013.01 - KR); C07K 2319/03 (2013.01 - KR); C07K 2319/21 (2013.01 - EP US); C07K 2319/30 (2013.01 - EP); C07K 2319/33 (2013.01 - EP); C12N 2510/00 (2013.01 - EP KR)
Citation (search report)
- [X] WO 2016154621 A1 20160929 - CALIFORNIA INST BIOMEDICAL RES [US]
- [XD] WO 2016168773 A2 20161020 - CALIFORNIA INST BIOMEDICAL RES [US]
- [X] JENNIFER S. Y. MA ET AL: "Versatile strategy for controlling the specificity and activity of engineered T cells", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 113, no. 4, 12 January 2016 (2016-01-12), US, pages E450 - E458, XP055678633, ISSN: 0027-8424, DOI: 10.1073/pnas.1524193113
- [X] M CARTELLIERI ET AL: "Switching CAR T cells on and off: a novel modular platform for retargeting of T cells to AML blasts", BLOOD CANCER JOURNAL, vol. 6, no. 8, 1 August 2016 (2016-08-01), pages e458 - e458, XP055532158, DOI: 10.1038/bcj.2016.61
- [T] JUSTIN R. KLESMITH ET AL: "Retargeting CD19 Chimeric Antigen Receptor T Cells via Engineered CD19-Fusion Proteins", MOLECULAR PHARMACEUTICS, vol. 16, no. 8, 26 June 2019 (2019-06-26), US, pages 3544 - 3558, XP055661080, ISSN: 1543-8384, DOI: 10.1021/acs.molpharmaceut.9b00418
- See also references of WO 2019203600A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
EP 3783026 A1 20210224; EP 3783026 A4 20210811; CN 111989342 A 20201124; JP 2021517907 A 20210729; KR 102251028 B1 20210512; KR 102398701 B1 20220517; KR 20190121716 A 20191028; KR 20210058769 A 20210524; US 11945878 B2 20240402; US 2021130490 A1 20210506; WO 2019203600 A1 20191024
DOCDB simple family (application)
EP 19787870 A 20190418; CN 201980026597 A 20190418; JP 2020557989 A 20190418; KR 20190045743 A 20190418; KR 2019004720 W 20190418; KR 20210058341 A 20210506; US 201917048739 A 20190418