EP 3794102 A1 20210324 - DEVICE AND METHOD FOR CULTIVATING CELLS IN A SHAKING OPERATION
Title (en)
DEVICE AND METHOD FOR CULTIVATING CELLS IN A SHAKING OPERATION
Title (de)
VORRICHTUNG UND VERFAHREN ZUR KULTIVIERUNG VON ZELLEN IM SCHÜTTELBETRIEB
Title (fr)
DISPOSITIF ET PROCÉDÉ DE CULTURE DE CELLULES DANS LE MODE D'AGITATION
Publication
Application
Priority
- DE 102018003910 A 20180516
- EP 2019061768 W 20190508
Abstract (en)
[origin: WO2019219465A1] The problem addressed by the present invention is that of providing a device by means of which the cultivation of cells can take place during passive gassing in a shaking operation, together with optimal gas exchange 10 between the headspace gas phase 3 and the ambient gas phase 6 and optimal gas blending within the headspace 3. According to the invention, the problem is solved by means of a device for cultivating cells in a shaking operation, the claimed device comprising at least one gas exchange opening 4, the opening surface of which is not aligned in parallel with the movement vector 9 of the shaking movement. Owing to the shaking movement and the ambient gas phase 6 flowing around the outside of the device and the headspace gas phase 3 flowing around the inside of the device according to the invention, which flowing is associated with the shaking, the arrangement leads to the formation of a pressure gradient between the headspace gas phase 3 and the ambient gas phase 6, which pressure gradient changes depending on the shaking movement and advantageously influences the gas exchange between the headspace gas phase 3 and the ambient gas phase 6 and the gas blending within the headspace 3.
IPC 8 full level
C12M 1/24 (2006.01); C12M 1/04 (2006.01); C12M 1/34 (2006.01); C12M 3/06 (2006.01)
CPC (source: EP US)
C12M 23/08 (2013.01 - EP US); C12M 23/24 (2013.01 - EP US); C12M 27/16 (2013.01 - EP US); C12M 41/34 (2013.01 - EP US); C12M 41/42 (2013.01 - EP US)
Citation (search report)
See references of WO 2019219465A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
DE 102018003910 B3 20190704; DE 102018003910 B8 20190905; EP 3794102 A1 20210324; US 2021189311 A1 20210624; WO 2019219465 A1 20191121
DOCDB simple family (application)
DE 102018003910 A 20180516; EP 19724379 A 20190508; EP 2019061768 W 20190508; US 201917054364 A 20190508