Title (en)

A SYSTEM FOR IDENTIFICATION OF ANTIGENS RECOGNIZED BY T CELL RECEPTORS EXPRESSED ON TUMOR INFILTRATING LYMPHOCYTES

Title (de)

SYSTEM ZUR IDENTIFIZIERUNG VON ANTIGENEN, DIE VON T-ZELL-REZEPTOREN ERKANNT WERDEN, DIE AUF TUMORINFILTRIERENDEN LYMPHOZYTEN EXPRIMIERT WERDEN

Title (fr)

SYSTÈME D'IDENTIFICATION D'ANTIGÈNES RECONNUS PAR DES RÉCEPTEURS DE LYMPHOCYTES T EXPRIMÉS SUR DES LYMPHOCYTES INFILTRANT LES TUMEURS

Publication

EP 3807636 A1 20210421 (EN)

Application

EP 19731265 A 20190614

Priority

• US 201862685469 P 20180615
• EP 2019065717 W 20190614

Abstract (en)

[origin: WO2019238939A1] The invention is a method of identifying a cognate antigen for a T-cell receptor using neoantigens from a patient's tumor cells combined with the patient's T-cells and using cell sorting, genome sequencing, expressing TCR genes, presenting tumor neoantigens on MHC complex and uniquely barcoding the T-cells where TCR recognition occurs to tag all components of the TCR recognition complex.

IPC 8 full level

G01N 33/50 (2006.01); C12N 15/10 (2006.01); C12Q 1/6806 (2018.01); C12Q 1/6881 (2018.01); C12Q 1/6883 (2018.01); G01N 33/569 (2006.01)

CPC (source: EP US)

C12N 15/1034 (2013.01 - EP US); C12Q 1/6806 (2013.01 - EP US); C12Q 1/6881 (2013.01 - EP US); C12Q 1/6883 (2013.01 - EP US); G01N 33/56977 (2013.01 - EP)

Citation (search report)

See references of WO 2019238939A1

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Designated extension state (EPC)

BA ME

DOCDB simple family (publication)

WO 2019238939 A1 20191219; CN 112292600 A 20210129; EP 3807636 A1 20210421; EP 3807636 B1 20240131; JP 2021526382 A 20211007; JP 7145980 B2 20221003; US 11603565 B2 20230314; US 2021285049 A1 20210916

DOCDB simple family (application)

EP 2019065717 W 20190614; CN 201980040057 A 20190614; EP 19731265 A 20190614; JP 2020568974 A 20190614; US 201917252222 A 20190614