EP 3830273 A4 20220518 - PROTEIN C-FACTOR VII CHIMERAS
Title (en)
PROTEIN C-FACTOR VII CHIMERAS
Title (de)
PROTEIN-C-FAKTOR-VII-CHIMÄREN
Title (fr)
CHIMÈRES DE FACTEUR VII DE PROTÉINE C
Publication
Application
Priority
- US 201862714189 P 20180803
- US 2019045018 W 20190803
Abstract (en)
[origin: WO2020028886A1] Provided are chimeric Protein C -Factor VII proteins comprising a Gla domain from Protein C (PC), an EGF-1 domain from PC, an EGF-2 domain from Factor VII (FVII), and a protease domain from FVII.
IPC 8 full level
A61K 38/00 (2006.01); A61K 38/48 (2006.01); A61P 7/02 (2006.01); C07K 14/745 (2006.01); C12N 15/62 (2006.01); C12N 15/63 (2006.01)
CPC (source: EP US)
A61P 7/02 (2017.12 - EP); C07K 14/745 (2013.01 - EP); C12N 9/6437 (2013.01 - US); C12N 9/6464 (2013.01 - US); A61K 38/00 (2013.01 - EP US); C07K 2319/00 (2013.01 - EP US); C07K 2319/01 (2013.01 - US)
Citation (search report)
- [I] WO 2012149463 A1 20121101 - UNIV NORTH CAROLINA [US], et al
- [I] WO 2008127702 A2 20081023 - CATALYST BIOSCIENCES INC [US], et al
- [A] NDONWI MATTHEW ET AL: "Substitution of the Gla Domain in Factor X with That of Protein C Impairs Its Interaction with Factor VIIa/Tissue Factor", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 282, no. 21, 1 May 2007 (2007-05-01), US, pages 15632 - 15644, XP055910197, ISSN: 0021-9258, DOI: 10.1074/jbc.M701908200
- [A] GLEESON E. M. ET AL: "A novel protein C-factor VII chimera provides new insights into the structural requirements for cytoprotective protease-activated receptor 1 signaling", JOURNAL OF THROMBOSIS AND HAEMOSTASIS, vol. 15, no. 11, 21 September 2017 (2017-09-21), GB, pages 2198 - 2207, XP055910503, ISSN: 1538-7933, Retrieved from the Internet <URL:https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fjth.13807> DOI: 10.1111/jth.13807
- See references of WO 2020028886A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2020028886 A1 20200206; EP 3830273 A1 20210609; EP 3830273 A4 20220518; US 11560556 B2 20230124; US 2021301277 A1 20210930
DOCDB simple family (application)
US 2019045018 W 20190803; EP 19845511 A 20190803; US 201917265277 A 20190803