EP 3836951 A1 20210623 - PEPTIDES AND COMPOSITIONS FOR TARGETED TREATMENT AND IMAGING
Title (en)
PEPTIDES AND COMPOSITIONS FOR TARGETED TREATMENT AND IMAGING
Title (de)
PEPTIDE UND ZUSAMMENSETZUNGEN ZUR GEZIELTEN BEHANDLUNG UND ABBILDUNG
Title (fr)
PEPTIDES ET COMPOSITIONS POUR TRAITEMENT ET IMAGERIE CIBLÉS
Publication
Application
Priority
- US 201862717929 P 20180813
- US 201862751303 P 20181026
- US 201962836823 P 20190422
- US 201962843835 P 20190506
- US 201962875287 P 20190717
- US 2019046392 W 20190813
Abstract (en)
[origin: WO2020036987A1] The invention disclosed herein provides compositions and methods of treating cancer and other diseases related to activated immune cells using modulators of the TREM-1/DAP-12 signaling pathway. The compositions, including peptides and peptide variants, modulate TREM- 1 -mediated immunological response as standalone and combination-therapy treatment regimen. Further, methods are provided for predicting the efficacy of TREM-l modulatory therapies in patients. In one embodiment, the present invention relates to targeted treatment, prevention and/or detection of cancer including but not limited to lung cancer including non-small cell lung cancer, pancreatic cancer, giant cell tumor of the tendon sheath, tenosynovial giant cell tumor, pigmented villonodular synovitis, cancer cachexia, etc., and other cancers associated with myeloid cell activation and recruitment. Additionally, the present invention relates to the targeted treatment, prevention and/or detection of scleroderma including but not limited to calcinosis, Raynaud's phenomenon, esophageal dysmotility, scleroderma, or telangiectasia syndrome (CREST). The invention further relates to personalized medical treatments.
IPC 8 full level
A61K 38/08 (2019.01); A61K 38/10 (2006.01); A61K 38/17 (2006.01); A61K 39/00 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01)
CPC (source: EP US)
A61K 38/08 (2013.01 - EP); A61K 38/10 (2013.01 - EP); A61K 38/1774 (2013.01 - EP); A61K 39/001111 (2018.08 - EP US); A61K 45/06 (2013.01 - EP); A61P 1/16 (2018.01 - EP); A61P 7/00 (2018.01 - EP); A61P 19/02 (2018.01 - EP); A61P 27/02 (2018.01 - EP); A61P 35/00 (2018.01 - EP); A61K 2039/55516 (2013.01 - EP); A61K 2300/00 (2013.01 - EP)
C-Set (source: EP)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2020036987 A1 20200220; CA 3109702 A1 20200220; EP 3836951 A1 20210623
DOCDB simple family (application)
US 2019046392 W 20190813; CA 3109702 A 20190813; EP 19769270 A 20190813