EP 3844154 A1 20210707 - IONIZABLE LIPIDOIDS AND THEIR USES
Title (en)
IONIZABLE LIPIDOIDS AND THEIR USES
Title (de)
IONISIERBARE LIPIDOIDE UND IHRE VERWENDUNGEN
Title (fr)
LIPIDOÏDES IONISABLES ET LEURS UTILISATIONS
Publication
Application
Priority
- US 201862725445 P 20180831
- US 2019049050 W 20190830
Abstract (en)
[origin: WO2020047399A1] Provided herein are lipidoid compounds of Formulae (I) and (II), and pharmaceutically acceptable salts, co-crystals, tautomers, stereoisomers, solvates, hydrates, polymorphs, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive lipidoid compounds, compositions, or formulations for treating and/or preventing diseases (e.g., genetic disease, proliferative disease, hematological disease, neurological disease, painful condition, psychiatric disorder, metabolic disorder, long-term medical condition, inflammatory disease, autoinflammatory disease, liver disease, lung disease, spleen disease, familial amyloid neuropathy, cardiovascular disease, viral infection, infectious disease, fibrotic condition, or autoimmune disease) in a subject, methods for synthesizing the compounds described herein, and compounds described herein synthesized by the synthetic methods described herein. The compounds are effective carriers for the delivery of an agent such as a polynucleotide (e.g., RNA) to a cell.
IPC 8 full level
C07D 233/26 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); C07C 233/00 (2006.01)
CPC (source: EP US)
A61K 39/39 (2013.01 - US); A61P 29/00 (2017.12 - EP); A61P 35/00 (2017.12 - EP); C07C 237/06 (2013.01 - US); C07C 237/16 (2013.01 - EP); C07C 251/08 (2013.01 - US); C07D 233/26 (2013.01 - EP); C07D 233/40 (2013.01 - US); C07D 403/06 (2013.01 - US); A61K 2039/53 (2013.01 - US); A61K 2039/55555 (2013.01 - US)
Citation (search report)
See references of WO 2020047399A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2020047399 A1 20200305; WO 2020047399 A8 20200423; AU 2019328523 A1 20210325; CA 3111278 A1 20200305; EP 3844154 A1 20210707; US 11459304 B2 20221004; US 2020109121 A1 20200409; US 2023257353 A1 20230817
DOCDB simple family (application)
US 2019049050 W 20190830; AU 2019328523 A 20190830; CA 3111278 A 20190830; EP 19769644 A 20190830; US 201916556470 A 20190830; US 202217875982 A 20220728