EP 3844297 A4 20220831 - PEPTIDES HAVING IMMUNOMODULATORY PROPERTIES
Title (en)
PEPTIDES HAVING IMMUNOMODULATORY PROPERTIES
Title (de)
PEPTIDE MIT IMMUNOMODULATORISCHEN EIGENSCHAFTEN
Title (fr)
PEPTIDES AYANT DES PROPRIÉTÉS IMMUNO-MODULATRICES
Publication
Application
Priority
US 2018048632 W 20180829
Abstract (en)
[origin: CN113039194A] The present invention provides novel peptides having immunomodulatory activity in vitro and in vivo. The peptides may include specific banding hydrophilic and hydrophobic regions consisting of alternating hydrophilic and hydrophobic modules, which may assume an amphiphilic conformation under physiological conditions. The present invention provides peptides that can specifically bind to key functional regions on one or more signaling proteins, in particular pro-inflammatory cytokines, macrophage inhibitory proteins and histone regulatory proteins. The invention includes peptides that are sufficiently stable in the circulation for intravenous administration. The invention also provides a pharmaceutical composition comprising the target peptide. The target peptides can be used in methods of modulating macrophage activity. In some cases, the peptide is a CD206 binding agent. The invention also provides methods of treating chronic inflammation related conditions in a subject using the peptides and compositions of the invention.
IPC 8 full level
C12Q 1/68 (2018.01)
CPC (source: EP KR)
A61K 31/337 (2013.01 - EP); A61K 31/7068 (2013.01 - EP); A61K 38/08 (2013.01 - KR); A61K 38/14 (2013.01 - EP); A61K 39/39 (2013.01 - EP); A61K 45/06 (2013.01 - EP); A61P 29/00 (2017.12 - EP KR); A61P 37/02 (2017.12 - KR); C07K 7/06 (2013.01 - EP KR); A61K 38/00 (2013.01 - EP); A61K 2039/55516 (2013.01 - EP)
Citation (search report)
- [ID] WO 2016061133 A1 20160421 - RIPTIDE BIOSCIENCE INC [US]
- [ID] US 2012270770 A1 20121025 - JAYNES JESSE MICHAEL [US]
- See references of WO 2020046297A2
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2020046297 A2 20200305; AU 2018438604 A1 20210318; CA 3110618 A1 20200305; CN 113039194 A 20210625; EP 3844297 A2 20210707; EP 3844297 A4 20220831; JP 2022511280 A 20220131; JP 2023145635 A 20231011; KR 20210052473 A 20210510; ZA 202101327 B 20220928
DOCDB simple family (application)
US 2018048632 W 20180829; AU 2018438604 A 20180829; CA 3110618 A 20180829; CN 201880098522 A 20180829; EP 18931536 A 20180829; JP 2021510646 A 20180829; JP 2023123680 A 20230728; KR 20217008293 A 20180829; ZA 202101327 A 20210226