EP 3845521 A2 20210707 - SYNTHESIS METHODS FOR UPADACITINIB AND INTERMEDIATE THEREOF
Title (en)
SYNTHESIS METHODS FOR UPADACITINIB AND INTERMEDIATE THEREOF
Title (de)
SYNTHESEVERFAHREN FÜR UPADACITINIB UND ZWISCHENPRODUKT DAVON
Title (fr)
PROCÉDÉS DE SYNTHÈSE DE L'UPADACITINIB ET D'UN INTERMÉDIAIRE DE CELUI-CI
Publication
Application
Priority
- CN 2019102443 W 20190826
- CN 201811008444 A 20180831
- CN 201811083531 A 20180917
Abstract (en)
The present invention relates to a JAK inhibitor upadacitinib intermediate and a preparation method therefor, and to a preparation method for a JAK inhibitor upadacitinib. The upadacitinib intermediate of the present application is as shown in Formula (II) or Formula (III),wherein, R is a protective group of nitrogen atoms, and R<sub>1</sub> is an open-chain or cyclic amine group. Compared with the prior art, the method for the synthesis of upadacitinib of the present application, under the premise of ensuring the yield, significantly reduces cost, is environmentally-friendly, and improves the quality of the final product.
IPC 8 full level
C07D 207/04 (2006.01); C07D 241/20 (2006.01); C07D 487/14 (2006.01)
CPC (source: EP US)
C07D 207/08 (2013.01 - EP US); C07D 207/16 (2013.01 - US); C07D 241/20 (2013.01 - US); C07D 487/04 (2013.01 - EP US); C07D 487/14 (2013.01 - EP US); Y02P 20/55 (2015.11 - EP)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
EP 3845521 A2 20210707; EP 3845521 A4 20220824; US 11926633 B2 20240312; US 2021323971 A1 20211021; WO 2020043033 A2 20200305; WO 2020043033 A3 20200416
DOCDB simple family (application)
EP 19855338 A 20190826; CN 2019102443 W 20190826; US 201917272369 A 20190826