EP 3846787 A4 20220525 - NOVEL COMPOSITION OF LAPATINIB OF ORAL SOLID DOSAGE FORM AND METHOD OF MANUFACTURING THEREOF
Title (en)
NOVEL COMPOSITION OF LAPATINIB OF ORAL SOLID DOSAGE FORM AND METHOD OF MANUFACTURING THEREOF
Title (de)
NEUARTIGE ZUSAMMENSETZUNG VON LAPATINIB IN ORALER FESTER DARREICHUNGSFORM UND VERFAHREN ZU IHRER HERSTELLUNG
Title (fr)
NOUVELLE COMPOSITION DE LAPATINIB DE FORME GALÉNIQUE ORALE SOLIDE ET PROCÉDÉ DE FABRICATION
Publication
Application
Priority
- IN 201821032977 A 20180903
- IB 2019057324 W 20190830
Abstract (en)
[origin: WO2020049429A1] The present invention discloses a novel pharmaceutical composition of lapatinib or a pharmaceutically acceptable salt thereof preferably oral solid dosage form of a tablet with pharmaceutically acceptable excipients and method of preparation thereof. The pharmaceutical composition of present invention comprises lapatinib ditosylate monohydrate with one or more pharmaceutically acceptable excipients selected from the group comprising of at least one diluent, at least one disintegrant, at least one binder, at least one lubricant, wherein the composition does not comprise microcrystalline cellulose and sodium starch glycolate. The pharmaceutical composition according to the present invention is economical and advanced dosage form over existing dosage form, with less side effects and time efficient, especially for large scale production, whereby the pharmaceutical composition shows a desired dissolution profile and higher stability with minimum use of excipients.
IPC 8 full level
A61K 9/20 (2006.01); A61K 31/517 (2006.01); C07D 405/04 (2006.01)
CPC (source: EP)
A61K 9/2018 (2013.01); A61K 9/2027 (2013.01); A61K 31/517 (2013.01); A61P 35/00 (2017.12); A61K 9/2866 (2013.01)
Citation (search report)
- [XDI] WO 2010023188 A1 20100304 - RATIOPHARM GMBH [DE], et al
- [XDI] WO 2010023187 A1 20100304 - RATIOPHARM GMBH [DE], et al
- [XI] CN 106511289 A 20170322 - HUBEI BIO-PHARMACEUTICAL IND TECH INST INC
- [X] WO 2011146710 A1 20111124 - GLAXOSMITHKLINE LLC [US], et al
- See references of WO 2020049429A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2020049429 A1 20200312; BR 112021004047 A2 20210525; CL 2021000512 A1 20211126; EP 3846787 A1 20210714; EP 3846787 A4 20220525; MX 2021002441 A 20210325; PH 12021550451 A1 20210927; ZA 202101538 B 20220727
DOCDB simple family (application)
IB 2019057324 W 20190830; BR 112021004047 A 20190830; CL 2021000512 A 20210301; EP 19857473 A 20190830; MX 2021002441 A 20190830; PH 12021550451 A 20210302; ZA 202101538 A 20210305