EP 3852773 A1 20210728 - CELLULAR COMPOSITIONS DERIVED FROM DECEASED DONORS TO PROMOTE GRAFT TOLERANCE AND MANUFACTURE AND USES THEREOF
Title (en)
CELLULAR COMPOSITIONS DERIVED FROM DECEASED DONORS TO PROMOTE GRAFT TOLERANCE AND MANUFACTURE AND USES THEREOF
Title (de)
AUS VERSTORBENEN SPENDERN GEWONNENE ZELLULÄRE ZUSAMMENSETZUNGEN ZUR FÖRDERUNG DER TRANSPLANTATIONSTOLERANZ UND HERSTELLUNG UND VERWENDUNGEN DAVON
Title (fr)
COMPOSITIONS CELLULAIRES DÉRIVÉES DE DONNEURS DÉCÉDÉS FAVORISANT LA TOLÉRANCE À LA GREFFE, FABRICATION ET UTILISATIONS
Publication
Application
Priority
- US 201862732823 P 20180918
- US 201862732830 P 20180918
- US 201862732832 P 20180918
- US 201862732827 P 20180918
- US 2019051711 W 20190918
Abstract (en)
[origin: WO2020061180A1] The invention provides cellular compositions that contain CD34+ cells derived from bone marrow of a decease donor and CD3+ cells derived from non-bone marrow of the deceased donor. The compositions are useful to promote mixed chimerism in recipients of solid organ transplants. The invention also provides methods of making and using such compositions. In certain embodiments, the invention further provides methods of analyzing and preparing blood and blood components from a deceased donor for use in compositions of the invention to promote mixed chimerism in solid organ transplant recipients.
IPC 8 full level
A61K 35/28 (2015.01); A61K 41/00 (2020.01); A61P 37/06 (2006.01); C12N 5/071 (2010.01); C12N 5/0789 (2010.01)
CPC (source: EP)
A61K 35/14 (2013.01); A61K 35/17 (2013.01); A61K 35/26 (2013.01); A61K 35/28 (2013.01); A61K 35/407 (2013.01); A61K 35/545 (2013.01); A61P 37/06 (2018.01); C12N 5/0669 (2013.01)
C-Set (source: EP)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2020061180 A1 20200326; AU 2019344937 A1 20210408; CA 3112320 A1 20200326; CN 113164517 A 20210723; EP 3852773 A1 20210728; EP 3852773 A4 20220629; JP 2022502483 A 20220111
DOCDB simple family (application)
US 2019051711 W 20190918; AU 2019344937 A 20190918; CA 3112320 A 20190918; CN 201980075888 A 20190918; EP 19861568 A 20190918; JP 2021539495 A 20190918