Global Patent Index - EP 3858985 A1

EP 3858985 A1 20210804 - METHOD FOR RAPID GENERATION OF AN ATTENUATED RNA VIRUS

Title (en)

METHOD FOR RAPID GENERATION OF AN ATTENUATED RNA VIRUS

Title (de)

VERFAHREN ZUR SCHNELLEN ERZEUGUNG EINES ABGESCHWÄCHTEN RNA-VIRUS

Title (fr)

PROCÉDÉ DE GÉNÉRATION RAPIDE D'UN VIRUS À ARN ATTÉNUÉS

Publication

EP 3858985 A1 20210804 (EN)

Application

EP 21154031 A 20150619

Priority

  • EP 14305956 A 20140620
  • EP 15731884 A 20150619
  • EP 2015063815 W 20150619

Abstract (en)

The present invention harnesses the power of mutagenesis to produce an attenuated RNA virus in a very short period, i.e. as soon as the complete sequence of the target virus is known and an infectious genome can be produced.

IPC 8 full level

C12N 7/00 (2006.01); A61K 39/00 (2006.01)

CPC (source: CN EP US)

A61K 39/12 (2013.01 - US); A61P 31/14 (2017.12 - EP); C12N 7/00 (2013.01 - CN EP US); C12N 7/04 (2013.01 - US); C12N 15/1031 (2013.01 - US); A61K 2039/525 (2013.01 - CN EP US); A61K 2039/5254 (2013.01 - US); C12N 2770/24051 (2013.01 - CN EP US); C12N 2770/24062 (2013.01 - CN); C12N 2770/24151 (2013.01 - CN EP US); C12N 2770/24162 (2013.01 - CN); Y02A 50/30 (2017.12 - EP US)

Citation (applicant)

  • NOUGAIREDE ET AL.: "Random Codon Re-encoding Induces Stable Reduction of Replicative Fitness of Chikungunya Virus in primate and Mosquito Cells", PLOS PATHOGENS, 2013
  • "GenBank", Database accession no. KC196115
  • FABRITUS L ET AL.: "Attenuation of Tick-Borne Encephalitis Virus Using Large-Scale Random Codon Re-encoding", PLOS PATHOG, vol. 11, no. 3, 2015, XP055215494, DOI: 10.1371/journal.ppat.1004738

Citation (search report)

  • [Y] OMORI-URABE Y ET AL: "Needle-free jet injection of DNA and protein vaccine of the Far-Eastern subtype of tick-borne encephalitis virus induces protective immunity in mice : Needle free injection of TBEV vaccine", MICROBIOLOGY AND IMMUNOLOGY, vol. 55, no. 12, 1 December 2011 (2011-12-01), JP, pages 893 - 897, XP055816879, ISSN: 0385-5600, DOI: 10.1111/j.1348-0421.2011.00389.x
  • [Y] SCHMALJOHN C ET AL: "Naked DNA vaccines expressing the prM and E genes of Russian spring summer encephalitis virus and Central European encephalitis virus protect mice from homologous and heterologous challenge", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 71, no. 12, 1 December 1997 (1997-12-01), pages 9563 - 9569, XP002098268, ISSN: 0022-538X
  • [A] NOUGAIREDE A ET AL: "Random Codon Re-encoding Induces Stable Reduction of Replicative Fitness of Chikungunya Virus in Primate and Mosquito Cells", PLOS PATHOGENS, vol. 9, no. 2, 21 February 2013 (2013-02-21), pages e1003172, XP055149133, DOI: 10.1371/journal.ppat.1003172 & NOUGAIRÈDE A ET AL: "SUPPORTING INFORMATION: Text S1", 21 February 2013 (2013-02-21), XP055149137, Retrieved from the Internet <URL:http://www.plospathogens.org/article/fetchSingleRepresentation.action?uri=info:doi/10.1371/journal.ppat.1003172.s002> [retrieved on 20141027], DOI: 10.1371/journal.ppat.1003172.s002 & NOUGAIRÈDE A ET AL: "SUPPORTING INFORMATION: Text S2", 21 February 2013 (2013-02-21), XP055149139, Retrieved from the Internet <URL:http://www.plospathogens.org/article/fetchSingleRepresentation.action?uri=info:doi/10.1371/journal.ppat.1003172.s003> [retrieved on 20141027], DOI: 10.1371/journal.ppat.1003172.s003
  • [A] SIRIDECHADILOK B ET AL: "A Simplified Positive-Sense-RNA Virus Construction Approach That Enhances Analysis Throughput", JOURNAL OF VIROLOGY, vol. 87, no. 23, 1 December 2013 (2013-12-01), pages 12667 - 12674, XP055148748, ISSN: 0022-538X, DOI: 10.1128/JVI.02261-13
  • [AP] AUBRY F ET AL: "Single-stranded positive-sense RNA viruses generated in days using infectious subgenomic amplicons", JOURNAL OF GENERAL VIROLOGY, vol. 95, no. Pt_11, 22 July 2014 (2014-07-22), pages 2462 - 2467, XP055148751, ISSN: 0022-1317, DOI: 10.1099/vir.0.068023-0
  • [AP] DE FABRITUS L ET AL: "Attenuation of Tick-Borne Encephalitis Virus Using Large-Scale Random Codon Re-encoding", PLOS PATHOGENS, vol. 11, no. 3, 3 March 2015 (2015-03-03), pages e1004738, XP055215494, DOI: 10.1371/journal.ppat.1004738

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2015193473 A1 20151223; CN 106574253 A 20170419; EP 3158059 A1 20170426; EP 3158059 B1 20210310; EP 3858985 A1 20210804; ES 2873083 T3 20211103; HU E055036 T2 20211028; JP 2017518058 A 20170706; JP 6541695 B2 20190710; US 10619137 B2 20200414; US 2018201908 A1 20180719; US 2020270584 A1 20200827

DOCDB simple family (application)

EP 2015063815 W 20150619; CN 201580033015 A 20150619; EP 15731884 A 20150619; EP 21154031 A 20150619; ES 15731884 T 20150619; HU E15731884 A 20150619; JP 2016572676 A 20150619; US 201515315687 A 20150619; US 202016813179 A 20200309