EP 3859005 A4 20220629 - CARDIOTOXICITY ASSESSMENT METHOD
Title (en)
CARDIOTOXICITY ASSESSMENT METHOD
Title (de)
VERFAHREN ZUR BEURTEILUNG DER KARDIOTOXIZITÄT
Title (fr)
PROCÉDÉ D'ÉVALUATION DE CARDIOTOXICITÉ
Publication
Application
Priority
- JP 2018185533 A 20180928
- JP 2019033022 W 20190823
Abstract (en)
[origin: EP3859005A1] Provided is a cardiotoxicity assessment method which comprises: seeding cardiomyocytes in a culture container together with a culture medium; adding a drug to the culture medium in the culture container to bring the drug into contact with the cardiomyocytes; and measuring a heart disease biomarker secreted from the cardiomyocytes to assess cardiotoxicity of the drug, wherein at least a culture surface of the culture container is composed of an alicyclic structure-containing polymer, and the culture surface has a surface free energy of 30 to 37 mN/m.
IPC 8 full level
G01N 33/68 (2006.01); B01L 3/00 (2006.01); C12M 1/00 (2006.01); C12N 5/077 (2010.01)
CPC (source: EP US)
C12N 5/0657 (2013.01 - EP); G01N 33/5014 (2013.01 - US); G01N 33/5061 (2013.01 - US); G01N 33/6887 (2013.01 - EP); C12N 2503/02 (2013.01 - EP); C12N 2533/30 (2013.01 - EP); G01N 2333/58 (2013.01 - EP US); G01N 2500/10 (2013.01 - EP)
Citation (search report)
- [Y] US 2016209399 A1 20160721 - BOHLEN HERIBERT [DE], et al
- [Y] JP 2017079658 A 20170518 - NIPPON ZEON CO
- [A] US 2015291929 A1 20151015 - MURPHY WILLIAM L [US], et al
- [A] WO 2017010533 A1 20170119 - ZEON CORP [JP]
- See also references of WO 2020066396A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
EP 3859005 A1 20210804; EP 3859005 A4 20220629; CN 111989405 A 20201124; JP 7384167 B2 20231121; JP WO2020066396 A1 20210830; TW 202012936 A 20200401; TW I822860 B 20231121; US 2022034868 A1 20220203; WO 2020066396 A1 20200402
DOCDB simple family (application)
EP 19865332 A 20190823; CN 201980026140 A 20190823; JP 2019033022 W 20190823; JP 2020548180 A 20190823; TW 108133558 A 20190918; US 201917278823 A 20190823