EP 3862018 A4 20220629 - DISEASE TREATMENT DRUG BASED ON MESENCHYMAL-STEM-CELL MOBILIZATION
Title (en)
DISEASE TREATMENT DRUG BASED ON MESENCHYMAL-STEM-CELL MOBILIZATION
Title (de)
ARZNEIMITTEL ZUR BEHANDLUNG VON ERKRANKUNGEN AUF DER BASIS DER MOBILISIERUNG MESENCHYMALER STAMMZELLEN
Title (fr)
MÉDICAMENT DE TRAITEMENT DE MALADIES FONDÉ SUR LA MOBILISATION DE CELLULES SOUCHES MÉSENCHYMATEUSES
Publication
Application
Priority
- JP 2018190089 A 20181005
- JP 2019039231 W 20191004
Abstract (en)
[origin: EP3862018A1] The present inventors identified many nuclear proteins contained in the extract of skin tissue by mass spectrometry, randomly selected multiple partial amino acid sequences of the nuclear proteins, chemically synthesized peptides consisting of the partial amino acid sequences, and examined their activity of mobilizing mesenchymal stem cells. As a result, it was found that these multiple peptides show the activity of mobilizing mesenchymal stem cells into peripheral blood, even though their amino acid sequences are completely different from each other. The inventors also found that fragment peptides of the nuclear proteins have therapeutic effects on diseases characterized by inflammation and abnormalities of the immune system (e.g., inflammatory bowel disease and psoriasis). Based on these findings, a new regenerative medicine technology that can overcome the problems of cell transplantation therapy is provided.
IPC 8 full level
A61K 38/17 (2006.01); A61P 1/00 (2006.01); A61P 9/00 (2006.01); A61P 11/00 (2006.01); A61P 29/00 (2006.01); A61P 37/02 (2006.01); A61P 37/06 (2006.01); A61P 43/00 (2006.01); C07K 14/47 (2006.01); C12N 9/14 (2006.01)
CPC (source: EP US)
A61K 38/1709 (2013.01 - EP); A61P 1/00 (2018.01 - EP US); A61P 9/00 (2018.01 - EP); A61P 11/00 (2018.01 - EP); A61P 17/06 (2018.01 - US); A61P 29/00 (2018.01 - EP); A61P 37/02 (2018.01 - EP); A61P 37/06 (2018.01 - EP US); A61P 43/00 (2018.01 - EP); C07K 14/47 (2013.01 - EP); C07K 14/4702 (2013.01 - EP); C07K 14/4713 (2013.01 - US); C12N 9/14 (2013.01 - EP); C12Y 306/01003 (2013.01 - EP); A61K 38/00 (2013.01 - US); C07K 2319/09 (2013.01 - US)
Citation (search report)
- [XDY] EP 2055308 A1 20090506 - UNIV OSAKA [JP]
- [X] EP 2284255 A1 20110216 - GENOMIX CO LTD [JP], et al
- [X] EP 2494977 A1 20120905 - GENOMIX CO LTD [JP], et al
- [X] EP 2301560 A1 20110330 - GENOMIX CO LTD [JP], et al
- [Y] KR 20150026839 A 20150311 - CATHOLIC UNIV IND ACAD COOP [KR]
- [X] TAMAI K. ET AL: "PDGFR -positive cells in bone marrow are mobilized by high mobility group box 1 (HMGB1) to regenerate injured epithelia", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 108, no. 16, 4 April 2011 (2011-04-04), pages 6609 - 6614, XP055841405, ISSN: 0027-8424, DOI: 10.1073/pnas.1016753108
- [Y] CHAN JAMES K. ET AL: "Alarmins: awaiting a clinical response", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 122, no. 8, 1 August 2012 (2012-08-01), GB, pages 2711 - 2719, XP055866161, ISSN: 0021-9738, DOI: 10.1172/JCI62423
- See also references of WO 2020071519A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
EP 3862018 A1 20210811; EP 3862018 A4 20220629; CN 113382743 A 20210910; JP 7452798 B2 20240319; JP WO2020071519 A1 20210902; US 2021347839 A1 20211111; WO 2020071519 A1 20200409
DOCDB simple family (application)
EP 19869379 A 20191004; CN 201980077484 A 20191004; JP 2019039231 W 20191004; JP 2020551097 A 20191004; US 201917282872 A 20191004