Global Patent Index - EP 3863687 A4

EP 3863687 A4 20220831 - ANTIBODIES DIRECTED TO FILAMIN-A AND THERAPEUTIC USES THEREOF

Title (en)

ANTIBODIES DIRECTED TO FILAMIN-A AND THERAPEUTIC USES THEREOF

Title (de)

GEGEN FILAMIN-A GERICHTETE ANTIKÖRPER UND THERAPEUTISCHE VERWENDUNGEN DAVON

Title (fr)

ANTICORPS DIRIGÉS CONTRE LA FILAMINE-A ET LEURS UTILISATIONS THÉRAPEUTIQUES

Publication

EP 3863687 A4 20220831 (EN)

Application

EP 19871405 A 20191009

Priority

  • US 201862743169 P 20181009
  • US 2019055401 W 20191009

Abstract (en)

[origin: WO2020076954A1] The disclosure teaches antibodies that are useful, inter alia, in methods for detecting and treating human cancer. In a particular aspect, the disclosure teaches novel antibodies that are useful for detecting and treating human breast cancer. In some embodiments, the disclosure teaches novel antibodies that bind to filamin A. In some embodiments, the antibodies are intrabodies.

IPC 8 full level

C07K 16/30 (2006.01); A61K 51/10 (2006.01); C07K 16/46 (2006.01)

CPC (source: EP IL KR US)

A61K 47/62 (2017.08 - KR); A61K 51/10 (2013.01 - KR); A61K 51/1093 (2013.01 - KR); A61P 35/00 (2018.01 - EP IL KR US); C07K 16/18 (2013.01 - EP IL KR US); C07K 16/2809 (2013.01 - KR); C07K 16/30 (2013.01 - EP IL); G01N 33/57415 (2013.01 - KR US); G01N 33/6854 (2013.01 - KR); A61K 2039/505 (2013.01 - KR); A61K 2039/80 (2018.08 - EP IL); A61K 2039/812 (2018.08 - EP IL KR); A61K 2039/86 (2018.08 - EP IL); A61K 2039/884 (2018.08 - EP IL); C07K 2317/24 (2013.01 - EP IL KR US); C07K 2317/33 (2013.01 - US); C07K 2317/565 (2013.01 - KR); C07K 2317/622 (2013.01 - EP IL KR US); C07K 2317/70 (2013.01 - EP IL KR); C07K 2317/73 (2013.01 - EP IL KR US); C07K 2317/80 (2013.01 - EP IL KR US); C07K 2317/92 (2013.01 - KR US); G01N 2333/4712 (2013.01 - US)

Citation (search report)

  • [Y] WO 2018085431 A1 20180511 - BERG LLC [US], et al
  • [Y] SHOBHA RAVIPATY ET AL: "Clinical Validation of a Serum Protein Panel (FLNA, FLNB and KRT19) for Diagnosis of Prostate Cancer", JOURNAL OF MOLECULAR BIOMARKERS & DIAGNOSIS, vol. 08, no. 02, 1 January 2017 (2017-01-01), XP055489786, DOI: 10.4172/2155-9929.1000323
  • [Y] BU ZIBIN ET AL: "A Monoclonal Antibody SZ-117 That Recognizes Filamin A Derived from Tumor Cells", HYBRIDOMA, vol. 31, no. 3, 1 June 2012 (2012-06-01), US, pages 214 - 218, XP055944099, ISSN: 1554-0014, DOI: 10.1089/hyb.2011.0109
  • [Y] R. G. BEDOLLA ET AL: "Nuclear versus Cytoplasmic Localization of Filamin A in Prostate Cancer: Immunohistochemical Correlation with Metastases", CLINICAL CANCER RESEARCH, vol. 15, no. 3, 1 February 2009 (2009-02-01), pages 788 - 796, XP055083300, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-08-1402
  • [Y] JI ZHI-MIN ET AL: "Silencing Filamin A Inhibits the Invasion and Migration of Breast Cancer Cells by Up-regulating 14-3-3[sigma]", CURRENT MEDICAL SCIENCE, HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY, WUHAN, vol. 38, no. 3, 22 June 2018 (2018-06-22), pages 461 - 466, XP036617326, ISSN: 2096-5230, [retrieved on 20180622], DOI: 10.1007/S11596-018-1901-6
  • [Y] RAJESH K NALLAPALLI ET AL: "Targeting filamin A reduces K-RAS-induced lung adenocarcinomas and endothelial response to tumor growth in", MOLECULAR CANCER, BIOMED CENTRAL, LONDON, GB, vol. 11, no. 1, 2 August 2012 (2012-08-02), pages 50, XP021115999, ISSN: 1476-4598, DOI: 10.1186/1476-4598-11-50
  • [Y] SAVOY ROSALINDA M ET AL: "The dual role of filamin A in cancer: can't live with (too much of) it, can't live without it", ENDOCRINE RELATED CANCER, vol. 20, no. 6, 9 October 2013 (2013-10-09), GB, pages R341 - R356, XP055943880, ISSN: 1351-0088, DOI: 10.1530/ERC-13-0364
  • [Y] GIANPIETRO DOTTI ET AL: "Design and development of therapies using chimeric antigen receptor-expressing T cells", IMMUNOLOGICAL REVIEWS, WILEY-BLACKWELL PUBLISHING, INC, US, vol. 257, no. 1, 13 December 2013 (2013-12-13), pages 107 - 126, XP071455751, ISSN: 0105-2896, DOI: 10.1111/IMR.12131
  • [Y] JULIA STIEGLMAIER ET AL: "Utilizing the BiTE (bispecific T-cell engager) platform for immunotherapy of cancer", EXPERT OPINION ON BIOLOGICAL THERAPY, vol. 15, no. 8, 3 August 2015 (2015-08-03), pages 1093 - 1099, XP055465777, ISSN: 1471-2598, DOI: 10.1517/14712598.2015.1041373
  • [Y] ANDREA LJ MARSCHALL ET AL: "Specific in vivo knockdown of protein function by intrabodies", MABS, vol. 7, no. 6, 7 August 2015 (2015-08-07), US, pages 1010 - 1035, XP055572240, ISSN: 1942-0862, DOI: 10.1080/19420862.2015.1076601
  • See also references of WO 2020076954A1

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2020076954 A1 20200416; AU 2019358060 A1 20210429; CA 3115077 A1 20200416; CN 113164633 A 20210723; CN 113164633 B 20231121; EP 3863687 A1 20210818; EP 3863687 A4 20220831; IL 281932 A 20210531; JP 2022512644 A 20220207; JP 2024003141 A 20240111; JP 7442769 B2 20240305; KR 20210075132 A 20210622; US 2022025025 A1 20220127

DOCDB simple family (application)

US 2019055401 W 20191009; AU 2019358060 A 20191009; CA 3115077 A 20191009; CN 201980080604 A 20191009; EP 19871405 A 20191009; IL 28193221 A 20210331; JP 2021519606 A 20191009; JP 2023192525 A 20231110; KR 20217013718 A 20191009; US 201917283434 A 20191009