Global Patent Index - EP 3866981 A4

EP 3866981 A4 20220907 - METHODS FOR GENERATING THERAPEUTIC DELIVERY PLATFORMS

Title (en)

METHODS FOR GENERATING THERAPEUTIC DELIVERY PLATFORMS

Title (de)

VERFAHREN ZUR HERSTELLUNG THERAPEUTISCHER ABGABEPLATTFORMEN

Title (fr)

PROCÉDÉS DE GÉNÉRATION DE PLATES-FORMES D'ADMINISTRATION THÉRAPEUTIQUE

Publication

EP 3866981 A4 20220907 (EN)

Application

EP 19875362 A 20191021

Priority

  • US 201862748470 P 20181021
  • US 2019057237 W 20191021

Abstract (en)

[origin: WO2020086471A1] Methods for producing engineered exosomes and other vesicle-like biological targets in a microfluidic device, including allowing a target vesicle-like structure to react and bind with immunomagnetic particles; capturing the immunomagnetic particle/vesicle complex by applying a magnetic field; further engineering the captured vesicles by surface modifying with additional active moieties or internally loading with active agents; and releasing the engineered vesicle-like structures, such as by photolytically cleaving a linkage between the particle and engineered vesicle-like structures, thereby releasing intact vesicle-like structures which can act as delivery vehicles for therapeutic treatments.

IPC 8 full level

B03C 1/30 (2006.01); B03C 1/02 (2006.01); G01N 33/00 (2006.01); G01N 33/48 (2006.01)

CPC (source: EP KR)

B03C 1/01 (2013.01 - EP); B03C 1/02 (2013.01 - KR); B03C 1/288 (2013.01 - EP); B03C 1/30 (2013.01 - KR); G01N 33/48 (2013.01 - KR); G01N 33/5076 (2013.01 - EP); G01N 33/54333 (2013.01 - EP); G01N 33/54366 (2013.01 - EP); B03C 2201/18 (2013.01 - EP); B03C 2201/26 (2013.01 - EP); G01N 33/487 (2013.01 - EP); G01N 33/49 (2013.01 - EP); G01N 33/491 (2013.01 - EP); G01N 33/4915 (2013.01 - EP)

Citation (search report)

  • [X] Z. ZHAO, J. SIBBITT; M. HE: "On-Chip Harvesting and Photo-Release of Immunogenic Extracellular Vesicles for Cancer Immunotherapy", MICROTAS 2017; 21ST INTERNATIONAL CONFERENCE ON MINIATURIZED SYSTEMS FOR CHEMISTRY AND LIFE SCIENCES (MICROTAS 2017), SAVANNAH, GEORGIA, USA, 22-26 OCTOBER 2017, vol. 2, 22 October 2017 (2017-10-22) - 26 October 2017 (2017-10-26), pages 898 - 899, XP009537868, ISBN: 978-1-7138-0272-3, Retrieved from the Internet <URL:https://www.proceedings.com/52575.html>
  • [X] QINGFU ZHU ET AL: "Microfluidic engineering of exosomes: editing cellular messages for precision therapeutics", LAB ON A CHIP, vol. 18, no. 12, 1 January 2018 (2018-01-01), UK, pages 1690 - 1703, XP055709479, ISSN: 1473-0197, DOI: 10.1039/C8LC00246K
  • [X] GISS D ET AL: "MICROFLUIDICS TO ISOLATE UNTAGGED PROTEINS FROM CELL EXTRACTS FOF VISUAL ANALYSIS BY ELECTRON MICROSCOPY", 17TH MICROAFFINITY PURIFICATION OF PROTEINS BASED ON PHOTOLYTIC ELUTION: TOWARD AN EFFICIENT MICROBEAD AFFINITY CHROMATOGRAPHY ON A CHIP ELECTROPHORESIS 27-31 OCTOBER 2013, FREIBURG, GERMANY, 31 October 2013 (2013-10-31), pages 1785 - 1787, XP055947895, Retrieved from the Internet <URL:https://www.rsc.org/images/loc/2013/PDFs/Papers/597_0776.pdf>
  • [I] MIN-SOO KIM ET AL: "Study on bead-based micro biochip and analytical system for protein detection", TRANSDUCERS, SOLID-STATE SENSORS, ACTUATORS AND MICROSYSTEMS, 12TH INN ATIONAL CONFERENCE ON, 2003, PISCATAWAY, NJ, USA,IEEE, 8 June 2003 (2003-06-08), pages 1267, XP032377732, ISBN: 978-0-7803-7731-8, DOI: 10.1109/SENSOR.2003.1217003
  • [XP] ZHENG ZHAO ET AL: "Microfluidic on-demand engineering of exosomes towards cancer immunotherapy", LAB ON A CHIP, vol. 19, no. 10, 1 January 2019 (2019-01-01), UK, pages 1877 - 1886, XP055754271, ISSN: 1473-0197, DOI: 10.1039/C8LC01279B
  • See references of WO 2020086471A1

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2020086471 A1 20200430; AU 2019368213 A1 20210603; BR 112021007508 A2 20210810; CA 3117030 A1 20200430; CN 113195103 A 20210730; EP 3866981 A1 20210825; EP 3866981 A4 20220907; IL 282538 A 20210630; JP 2022512762 A 20220207; KR 20210088594 A 20210714

DOCDB simple family (application)

US 2019057237 W 20191021; AU 2019368213 A 20191021; BR 112021007508 A 20191021; CA 3117030 A 20191021; CN 201980084740 A 20191021; EP 19875362 A 20191021; IL 28253821 A 20210421; JP 2021521369 A 20191021; KR 20217015448 A 20191021