EP 3873437 A4 20220803 - AQUEOUS PHARMACEUTICAL FORMULATIONS
Title (en)
AQUEOUS PHARMACEUTICAL FORMULATIONS
Title (de)
WÄSSRIGE PHARMAZEUTISCHE FORMULIERUNGEN
Title (fr)
FORMULATIONS PHARMACEUTIQUES AQUEUSES
Publication
Application
Priority
- US 201862753084 P 20181031
- CN 2019113112 W 20191024
Abstract (en)
[origin: WO2020088346A1] Provided are an aqueous pharmaceutical formulation comprising an antibody specific to the receptor of interleukin (IL) -6 (for example, Tocilizumab) and an effective amount of histidine for stabilizing the antibody. Said histidine is present in the aqueous pharmaceutical formulation at a concentration of 50 mM to 200 mM so as to achieve the stabilizing effect.
IPC 8 full level
A61K 9/08 (2006.01); A61K 39/00 (2006.01); A61K 47/16 (2006.01); C07K 16/28 (2006.01)
CPC (source: EP KR US)
A61K 9/0019 (2013.01 - EP KR US); A61K 9/08 (2013.01 - KR); A61K 39/3955 (2013.01 - EP); A61K 39/39591 (2013.01 - EP KR); A61K 47/183 (2013.01 - EP KR US); A61K 47/22 (2013.01 - KR); A61K 47/26 (2013.01 - EP KR US); C07K 16/2866 (2013.01 - EP KR US)
Citation (search report)
- [X] EP 2526963 A1 20121128 - CHUGAI PHARMACEUTICAL CO LTD [JP]
- [X] WO 2017147293 A1 20170831 - ELEVEN BIOTHERAPEUTICS INC [US]
- [X] WO 2018060210 A1 20180405 - ARES TRADING SA [CH]
- [A] LENE JORGENSEN ET AL: "Recent trends in stabilising peptides and proteins in pharmaceutical formulation-considerations in the choice of excipients", EXPERT OPINION ON DRUG DELIVERY, vol. 6, no. 11, 13 August 2009 (2009-08-13), GB, pages 1219 - 1230, XP055528446, ISSN: 1742-5247, DOI: 10.1517/17425240903199143
- [A] CHEN BEI ET AL: "Influence of histidine on the stability and physical properties of a fully human antibody in aqueous and solid forms", PHARMACEUTICAL RESEARCH, SPRINGER US, NEW YORK, vol. 20, no. 12, 1 December 2003 (2003-12-01), pages 1952 - 1960, XP002386671, ISSN: 0724-8741, DOI: 10.1023/B:PHAM.0000008042.15988.C0
- See references of WO 2020088346A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2020088346 A1 20200507; AU 2019372568 A1 20210520; BR 112021008155 A2 20210810; CA 3117245 A1 20200507; EP 3873437 A1 20210908; EP 3873437 A4 20220803; IL 282343 A 20210531; JP 2022506042 A 20220117; JP 2024041791 A 20240327; JP 7411652 B2 20240111; KR 20210094552 A 20210729; MA 54095 A 20220209; MX 2021005015 A 20210721; US 2021393783 A1 20211223
DOCDB simple family (application)
CN 2019113112 W 20191024; AU 2019372568 A 20191024; BR 112021008155 A 20191024; CA 3117245 A 20191024; EP 19879433 A 20191024; IL 28234321 A 20210414; JP 2021523191 A 20191024; JP 2023218125 A 20231225; KR 20217016403 A 20191024; MA 54095 A 20191024; MX 2021005015 A 20191024; US 201917290092 A 20191024