EP 3875089 A1 20210908 - TABLET CONTAINING ANTITUMOR AGENT
Title (en)
TABLET CONTAINING ANTITUMOR AGENT
Title (de)
TABLETTE MIT ANTITUMORMITTEL
Title (fr)
COMPRIMÉ CONTENANT UN AGENT ANTITUMORAL
Publication
Application
Priority
- JP 2018204852 A 20181031
- JP 2019042751 W 20191031
Abstract (en)
An object of the present invention is to provide a tablet containing a succinate salt of (S,E)-N-(1-((5-(2-((4-cyanophenyl)amino)-4-(propylamino)pyrimidin-5-yl)-pent-4-yn-1-yl)am ino)-1-oxopropan-2-yl)-4-(dimethylamino)-N-methylbut-2-enamide (Compound A) which is rapidly dissolved in a weakly acidic solution in order to prevent a decrease in bioavailability. According to the present invention, there is provided a tablet containing a succinate salt of (S,E)-N-(1-((5-(2-((4-cyanophenyl)amino)-4-(propylamino)pyrimidin-5-yl)-pent-4-yn-1-yl)am ino)-1-oxopropan-2-yl)-4-(dimethylamino)-N-methylbut-2-enamide (Compound A), at least one or more kinds selected from the group consisting of sugars and sugar alcohol, and crospovidone.
IPC 8 full level
A61K 31/505 (2006.01); A61K 9/20 (2006.01); A61K 47/12 (2006.01); A61K 47/26 (2006.01); A61K 47/32 (2006.01); A61P 35/00 (2006.01); A61P 35/02 (2006.01)
CPC (source: EP US)
A61K 9/2013 (2013.01 - EP US); A61K 9/2018 (2013.01 - EP US); A61K 9/2027 (2013.01 - EP US); A61K 9/2054 (2013.01 - EP US); A61K 9/2059 (2013.01 - EP US); A61K 31/505 (2013.01 - EP US); A61P 35/00 (2017.12 - EP); A61P 35/02 (2017.12 - EP)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
EP 3875089 A1 20210908; EP 3875089 A4 20211222; CN 112996514 A 20210618; JP WO2020090971 A1 20210916; US 2021244731 A1 20210812; WO 2020090971 A1 20200507
DOCDB simple family (application)
EP 19880458 A 20191031; CN 201980072297 A 20191031; JP 2019042751 W 20191031; JP 2020554034 A 20191031; US 202117243706 A 20210429