EP 3882385 A1 20210922 - AUTOMATED MANUFACTURING OF THREE-DIMENSIONAL CELL MATRICES WITH NANOFIBRES OF CONTROLLED ALIGNMENT AND UNIFORM CELL DISTRIBUTION
Title (en)
AUTOMATED MANUFACTURING OF THREE-DIMENSIONAL CELL MATRICES WITH NANOFIBRES OF CONTROLLED ALIGNMENT AND UNIFORM CELL DISTRIBUTION
Title (de)
AUTOMATISIERTE HERSTELLUNG VON DREIDIMENSIONALEN ZELLMATRIZEN MIT NANOFASERN MIT KONTROLLIERTER AUSRICHTUNG UND GLEICHMÄSSIGER ZELLVERTEILUNG
Title (fr)
FABRICATION AUTOMATIQUE DE MATRICES DE CELLULES TRIDIMENSIONNELLES AVEC DES NANOFIBRES À ALIGNEMENT CONTRÔLÉ ET DISTRIBUTION UNIFORME DE CELLULES
Publication
Application
Priority
PT 11614520 A 20200304
Abstract (en)
The present invention relates to a system and process for automatically manufacturing three-dimensional cell matrices with nanofibres of controlled alignment and uniform cell distribution throughout the thickness.The system of the present invention comprises a module for forming nanofibres by electrospinning, a module for collecting the nanofibres comprising two collecting cylinders (6,30), a module for deposition of the collected nanofibres comprising a deposition table (10) with linear movements (22) and rotation (24), a module for electropulverisation of cells comprising a capillary tube for electropulverisation of cells (13).The formation of the cell matrices occurs from the alternating linear movements of the deposition table (10) between the position of the nanofibre collection module and the electropulverisation module where the cells are seeded on the two-dimensional mesh layers of nanofibres.The present invention has application in the field of tissue engineering, in particular in regenerative medicine.
IPC 8 full level
D04H 1/728 (2012.01); D01D 5/00 (2006.01); D04H 3/016 (2012.01); D04H 3/045 (2012.01)
CPC (source: EP)
D01D 5/0076 (2013.01); D04H 1/728 (2013.01); D04H 3/016 (2013.01); D04H 3/045 (2013.01)
Citation (applicant)
- US 2349950 A 19440530 - ANTON FORMHALS
- US 2012009292 A1 20120112 - MITCHELL STUART B [US], et al
- US 2011142806 A1 20110616 - SCOTT-CARNELL LISA A [US], et al
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- US 8580181 B1 20131112 - BEACHLEY VINCE [US], et al
- LI ET AL., NANOLETTERS, vol. 3, no. 8, 2003, pages 1167
- LI ET AL., ADV. MATTER, vol. 16, no. 4, 2004, pages 361
- SHEIKH, NANOMEDICINE, 2015, pages 11
- LI, MATER. SCI. ENG. C., 2016, pages 68
Citation (search report)
- [XA] WO 2015138970 A1 20150917 - SCRIPPS HEALTH [US]
- [A] WO 2018175234 A1 20180927 - UNIV PITTSBURGH COMMONWEALTH SYS HIGHER EDUCATION [US], et al
- [A] WO 2007090102 A2 20070809 - UNIV CALIFORNIA [US], et al
- [A] WO 2005100654 A2 20051027 - RES TRIANGLE INST [US], et al
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
EP 3882385 A1 20210922; EP 3882385 B1 20230823; EP 3882385 C0 20230823
DOCDB simple family (application)
EP 21160776 A 20210304