EP 3883960 A4 20221109 - GDF15 ANALOGS AND METHODS FOR USE IN DECREASING BODY WEIGHT AND/OR REDUCING FOOD INTAKE
Title (en)
GDF15 ANALOGS AND METHODS FOR USE IN DECREASING BODY WEIGHT AND/OR REDUCING FOOD INTAKE
Title (de)
GDF15-ANALOGA UND VERFAHREN ZUR VERWENDUNG ZUR VERRINGERUNG DES KÖRPERGEWICHTS UND/ODER ZUR REDUZIERUNG DER NAHRUNGSAUFNAHME
Title (fr)
ANALOGUES DE GDF15 ET PROCÉDÉS DESTINÉS À ÊTRE UTILISÉS POUR DIMINUER LE POIDS CORPOREL ET/OU RÉDUIRE L'INGESTION D'ALIMENTS
Publication
Application
Priority
- US 201862769675 P 20181120
- IB 2019059945 W 20191119
Abstract (en)
[origin: WO2020104948A1] The present invention is related to the fusion proteins containing a half-life extension protein, a linker, and a GDF15 protein which function as GDF15 agonists. These GDF15 agonists may be useful in the treatment of obesity, reduction of body weight, decrease in food intake, or decrease of appetite.
IPC 8 full level
C07K 14/765 (2006.01); A61K 38/00 (2006.01); A61K 38/18 (2006.01); A61P 3/04 (2006.01); C07K 14/475 (2006.01)
CPC (source: EP IL KR US)
A61K 9/0019 (2013.01 - US); A61K 38/00 (2013.01 - KR); A61K 38/18 (2013.01 - EP IL KR US); A61P 3/04 (2018.01 - EP IL KR US); C07K 14/495 (2013.01 - EP IL KR US); C07K 14/765 (2013.01 - EP IL KR US); C07K 2319/00 (2013.01 - EP IL); C07K 2319/21 (2013.01 - EP IL KR); C07K 2319/31 (2013.01 - EP IL KR)
Citation (search report)
- [E] WO 2020084496 A1 20200430 - JANSSEN PHARMACEUTICA NV [BE], et al
- [A] SHANNON E MULLICAN ET AL: "GFRAL is the receptor for GDF I S and the ligand promotes weight loss in mice and nonhuman primates (includes Online methods and supplementary information", NATURE MEDICINE, 28 August 2017 (2017-08-28), pages 1 - 8+20PP, XP055427433, DOI: 10.1038/nm.4392
- [A] SHANNON E. MULLICAN ET AL: "Uniting GDF15 and GFRAL: Therapeutic Opportunities in Obesity and Beyond", TRENDS IN ENDOCRINOLOGY AND METABOLISM, vol. 29, no. 8, 1 June 2018 (2018-06-01), US, pages 560 - 570, XP055600819, ISSN: 1043-2760, DOI: 10.1016/j.tem.2018.05.002
- See also references of WO 2020104948A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2020104948 A1 20200528; AU 2019383019 A1 20210603; BR 112021009225 A2 20211005; CA 3120236 A1 20200528; CN 113474363 A 20211001; EA 202191424 A1 20210824; EP 3883960 A1 20210929; EP 3883960 A4 20221109; IL 283189 A 20210630; JO P20210111 A1 20230130; JP 2022513098 A 20220207; KR 20210094584 A 20210729; MX 2021005908 A 20210908; PH 12021551119 A1 20211122; SG 11202104952P A 20210629; US 2022315633 A1 20221006
DOCDB simple family (application)
IB 2019059945 W 20191119; AU 2019383019 A 20191119; BR 112021009225 A 20191119; CA 3120236 A 20191119; CN 201980089716 A 20191119; EA 202191424 A 20191119; EP 19886438 A 20191119; IL 28318921 A 20210513; JO P20210111 A 20191119; JP 2021527918 A 20191119; KR 20217018694 A 20191119; MX 2021005908 A 20191119; PH 12021551119 A 20210514; SG 11202104952P A 20191119; US 201917309328 A 20191119