Global Patent Index - EP 3900529 A4

EP 3900529 A4 20220413 - NON-HUMAN ANIMAL HAVING HUMAN IL-34, AND USE THEREFOR

Title (en)

NON-HUMAN ANIMAL HAVING HUMAN IL-34, AND USE THEREFOR

Title (de)

NICHTMENSCHLICHES TIER MIT MENSCHLICHEM IL-34 UND DESSEN VERWENDUNG

Title (fr)

ANIMAL NON HUMAIN AYANT UNE IL-34 HUMAINE, ET APPLICATION ASSOCIÉE

Publication

EP 3900529 A4 20220413 (EN)

Application

EP 19914084 A 20190318

Priority

  • US 201962797369 P 20190128
  • JP 2019011261 W 20190318

Abstract (en)

[origin: EP3900529A1] The present invention provides a non-human animal having human interleukin-34 (IL-34) in the body thereof; a method for producing a non-human animal having human microglia, which includes transplanting human CD34-positive hematopoietic stem cells into the non-human animal having human IL-34 in the body; and a method for producing human microglia, which includes obtaining human microglia from the non-human animal having human microglia.

IPC 8 full level

A01K 67/027 (2006.01); C07K 14/54 (2006.01); C12N 5/0786 (2010.01); C12N 15/09 (2006.01)

CPC (source: EP US)

A01K 67/027 (2013.01 - US); A01K 67/0271 (2013.01 - US); A01K 67/0275 (2013.01 - EP US); C07K 14/54 (2013.01 - EP); C12N 5/0622 (2013.01 - US); A01K 2207/12 (2013.01 - EP US); A01K 2207/15 (2013.01 - EP US); A01K 2217/052 (2013.01 - EP); A01K 2217/15 (2013.01 - EP); A01K 2227/105 (2013.01 - EP US); A01K 2267/03 (2013.01 - EP); A01K 2267/0337 (2013.01 - US)

Citation (search report)

  • [Y] WO 2018200669 A1 20181101 - CHILDRENS MEDICAL CENTER [US]
  • [Y] LLEWELLYN GEORGE N ET AL: "HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency", JOURNAL OF NEUROVIROLOGY, INFORMA HEALTHCARE, GB, vol. 24, no. 2, 18 December 2017 (2017-12-18), pages 192 - 203, XP036486245, ISSN: 1355-0284, [retrieved on 20171218], DOI: 10.1007/S13365-017-0604-2
  • [Y] TIM WILLINGER ET AL: "Improving human hemato-lymphoid-system mice by cytokine knock-in gene replacement", TRENDS IN IMMUNOLOGY, vol. 32, no. 7, July 2011 (2011-07-01), pages 321 - 327, XP028238170, ISSN: 1471-4906, [retrieved on 20110421], DOI: 10.1016/J.IT.2011.04.005
  • [XP] MATHEWS SAUMI ET AL: "HIV-1 induced neuropathology of a humanized microglial mouse", 1 March 2019 (2019-03-01), XP055897358, Retrieved from the Internet <URL:https://2jg4quetidw2blbbq2ixwziw-wpengine.netdna-ssl.com/wp-content/uploads/sites/2/posters/2019/1430_Mathews_0433.pdf> [retrieved on 20220303]
  • See references of WO 2020157997A1

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Designated extension state (EPC)

BA ME

DOCDB simple family (publication)

EP 3900529 A1 20211027; EP 3900529 A4 20220413; EP 3900529 B1 20240110; CN 113473849 A 20211001; JP 6886524 B2 20210616; JP WO2020157997 A1 20210218; US 11419317 B2 20220823; US 2021352877 A1 20211118; WO 2020157997 A1 20200806

DOCDB simple family (application)

EP 19914084 A 20190318; CN 201980090496 A 20190318; JP 2019011261 W 20190318; JP 2019544759 A 20190318; US 201916615578 A 20190318