EP 3917968 A1 20211208 - ANTIBODIES TO M(H)DM2/4 AND THEIR USE IN DIAGNOSING AND TREATING CANCER
Title (en)
ANTIBODIES TO M(H)DM2/4 AND THEIR USE IN DIAGNOSING AND TREATING CANCER
Title (de)
ANTIBODIES TO M(H)DM2/4 AND THEIR USE IN DIAGNOSING AND TREATING CANCER
Title (fr)
ANTICORPS DIRIGÉS CONTRE M(H)DM2/4 ET LEUR UTILISATION DANS LE DIAGNOSTIC ET LE TRAITEMENT DU CANCER
Publication
Application
Priority
US 2019015900 W 20190130
Abstract (en)
[origin: WO2020159504A1] The present invention relates, inter alia, to certain anti-M(H)DM2/4 antibodies (including chimeric and humanized antibodies) or antigen- binding fragments thereof, pharmaceutical compositions comprising anti-M(H)DM2/4 antibodies or antigen-binding fragments thereof, antibody-drug conjugates comprising anti-M(H)DM2/4 antibodies or antigen-binding fragments thereof bound to a cytotoxic drug, and the use of such antibodies, fragments, compositions and conjugates for treating cancer and/or for preventing metastases. For example, described herein are certain antibodies (including chimeric and humanized antibodies) or antigen-binding fragments thereof that specifically bind to extracellularly accessible epitopes of M(H)DM2/4 and inhibit tumor growth in vivo, pharmaceutical compositions comprising such antibodies or fragments, antibody-drug conjugates comprising such antibodies or fragments, and the use of such antibodies, fragments, compositions and conjugates for treating cancer or for preventing metastasis.
IPC 8 full level
C07K 16/32 (2006.01); A61K 39/395 (2006.01); A61P 35/00 (2006.01); C07K 16/40 (2006.01)
CPC (source: EP)
A61K 39/39558 (2013.01); A61P 35/00 (2017.12); C07K 16/32 (2013.01); C07K 16/40 (2013.01); A61K 2039/505 (2013.01); A61K 2039/545 (2013.01); C07K 2317/24 (2013.01); C07K 2317/34 (2013.01); C07K 2317/734 (2013.01)
Citation (search report)
See references of WO 2020159504A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2020159504 A1 20200806; AU 2019427766 A1 20210916; CA 3127776 A1 20200806; EP 3917968 A1 20211208
DOCDB simple family (application)
US 2019015900 W 20190130; AU 2019427766 A 20190130; CA 3127776 A 20190130; EP 19705076 A 20190130