EP 3924513 B1 20230412 - MITIGATING ADVERSE IMPACTS OF DETECTION SYSTEMS ON NUCLEIC ACIDS AND OTHER BIOLOGICAL ANALYTES
Title (en)
MITIGATING ADVERSE IMPACTS OF DETECTION SYSTEMS ON NUCLEIC ACIDS AND OTHER BIOLOGICAL ANALYTES
Title (de)
VERMINDERUNG VON NEGATIVEN AUSWIRKUNGEN VON DETEKTIONSSYSTEMEN AUF NUKLEINSÄUREN UND ANDEREN BIOLOGISCHEN ANALYTEN
Title (fr)
ATTÉNUATION D'IMPACTS DÉFAVORABLES DE SYSTÈMES DE DÉTECTION SUR DES ACIDES NUCLÉIQUES ET D'AUTRES ANALYTES BIOLOGIQUES
Publication
Application
Priority
- US 201962805495 P 20190214
- US 2020016956 W 20200206
Abstract (en)
[origin: US2020263246A1] A method for sequencing a population of nucleic acids, which includes (a) binding the population of nucleic acids with a fractionally labeled mixture of nucleotides, thereby forming a fractionally labeled population of nucleic acids, wherein the mixture includes nucleotide cognates for a common base type in the templates, and wherein a fraction of the nucleotide cognates for the common base type in the mixture are exogenously labeled nucleotides that produce a signal that is not produced by other nucleotide cognates for the common base type in the mixture; (b) detecting the signal from the fractionally labeled population of nucleic acids; and (c) repeating (a) and (b) using a second mixture of the fractionally labeled nucleotides, wherein the fraction of the exogenously labeled nucleotides is higher in the second mixture.
IPC 8 full level
C12Q 1/6869 (2018.01)
CPC (source: EP US)
C12Q 1/6869 (2013.01 - EP US); C12Q 1/6876 (2013.01 - US); G01N 21/6428 (2013.01 - US); C12Q 2565/10 (2013.01 - US); C12Q 2565/40 (2013.01 - US); G01N 2021/6439 (2013.01 - US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
US 11499189 B2 20221115; US 2020263246 A1 20200820; EP 3924513 A1 20211222; EP 3924513 B1 20230412; WO 2020167574 A1 20200820
DOCDB simple family (application)
US 202016783488 A 20200206; EP 20709092 A 20200206; US 2020016956 W 20200206