EP 3928784 A1 20211229 - COMPOSITIONS COMPRISING ACTRIIA POLYPEPTIDES FOR USE IN TREATING PULMONARY HYPERTENSION

Title (en)

COMPOSITIONS COMPRISING ACTRIIA POLYPEPTIDES FOR USE IN TREATING PULMONARY HYPERTENSION

Title (de)

ZUSAMMENSETZUNGEN ENTHALTEND ACTRIIA-POLYPEPTIDE ZUR VERWENDUNG BEI DER BEHANDLUNG VON PULMONALER HYPERTONIE

Title (fr)

COMPOSITIONS COMPRENANT DES POLYPEPTIDES ACTRIIA POUR LEUR UTILISATION DANS LE TRAITEMENT DE L'HYPERTENSION PULMONAIRE

Publication

EP 3928784 A1 20211229 (EN)

Application

EP 21163839 A 20170714

Priority

US 201662362955 P 20160715
US 201762453888 P 20170202
US 201762510403 P 20170524
EP 17828540 A 20170714
US 2017042157 W 20170714

Abstract (en)

In some aspects, the disclosure relates to GDF/BMP antagonists and methods of using GDF/BMP antagonists to treat, prevent, or reduce the progression rate and/or severity of pulmonary hypertension (PH), particularly treating, preventing or reducing the progression rate and/or severity of one or more PH-associated complications. The disclosure also provides methods of using a GDF/BMP antagonist to treat, prevent, or reduce the progression rate and/or severity of a variety of conditions including, but not limited to, pulmonary vascular remodeling, pulmonary fibrosis, and right ventricular hypertrophy. The disclosure further provides methods of using a GDF/BMP antagonist to reduce right ventricular systolic pressure in a subject in need thereof.

IPC 8 full level

A61K 38/17 (2006.01); A61K 47/68 (2017.01); A61P 7/00 (2006.01); A61P 11/00 (2006.01)

CPC (source: CN EP KR RU US)

A61K 31/7088 (2013.01 - CN KR); A61K 38/17 (2013.01 - CN RU); A61K 38/1709 (2013.01 - CN KR); A61K 38/179 (2013.01 - CN US); A61K 38/1796 (2013.01 - CN EP US); A61K 38/1875 (2013.01 - CN EP KR US); A61K 38/35 (2013.01 - CN RU); A61K 38/45 (2013.01 - CN EP KR US); A61K 39/3955 (2013.01 - CN KR); A61K 45/06 (2013.01 - CN EP KR US); A61K 47/68 (2017.08 - CN RU); A61P 7/00 (2018.01 - CN EP KR RU US); A61P 11/00 (2018.01 - CN EP KR RU US); C07K 14/71 (2013.01 - CN EP KR RU US); A61K 2039/505 (2013.01 - KR); C07K 2319/00 (2013.01 - KR); C07K 2319/30 (2013.01 - EP KR US); Y02A 50/30 (2018.01 - EP)

Citation (applicant)

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Citation (search report)

[Y] EP 2594280 A1 20130522 - BIOMEDICAL RES FOUNDATION OF THE ACADEMY OF ATHENS [GR], et al
[Y] AU 2012244215 A1 20121115 - ACCELERON PHARMA INC
[Y] DAVID MONTANI ET AL: "Pulmonary arterial hypertension", ORPHANET JOURNAL OF RARE DISEASES, BIOMED CENTRAL LTD, LO, vol. 8, no. 1, 6 July 2013 (2013-07-06), pages 97, XP021161659, ISSN: 1750-1172, DOI: 10.1186/1750-1172-8-97

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

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BA ME

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