EP 3939986 A1 20220119 - SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5)

Title (en)

SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5)

Title (de)

SELEKTIVE INHIBITOREN DER PROTEIN-ARGININ-METHYLTRANSFERASE 5 (PRMT5)

Title (fr)

INHIBITEURS SÉLECTIFS DE LA PROTÉINE ARGININE MÉTHYLTRANSFÉRASE 5 (PRMT5)

Publication

EP 3939986 A1 20220119 (EN)

Application

EP 21178139 A 20180809

Priority

US 201762543141 P 20170809
US 201862630581 P 20180214
US 201862664442 P 20180430
EP 18760136 A 20180809
US 2018046057 W 20180809

Abstract (en)

The disclosure is directed to compounds of Formula IPharmaceutical compositions comprising compounds of Formula I, as well as methods of their use and preparation, are also described.

IPC 8 full level

C07H 19/14 (2006.01); A61K 31/7064 (2006.01); A61P 35/00 (2006.01); A61P 35/02 (2006.01)

CPC (source: EP IL KR US)

A61K 31/7064 (2013.01 - EP IL KR US); A61P 35/00 (2018.01 - KR); A61P 35/02 (2018.01 - EP IL KR US); C07D 487/04 (2013.01 - EP IL US); C07D 519/00 (2013.01 - EP IL US); C07H 19/14 (2013.01 - EP IL KR US); A61K 2300/00 (2013.01 - IL)

C-Set (source: EP US)

A61K 31/7064 + A61K 2300/00

Citation (applicant)

US 5023252 A 19910611 - HSEIH DEAN [US]
US 4992445 A 19910212 - LAWTER JAMES R [US], et al
US 5001139 A 19910319 - LAWTER JAMES R [US], et al
US 5451233 A 19950919 - YOCK PAUL G [US]
US 5040548 A 19910820 - YOCK PAUL G [US]
US 5061273 A 19911029 - YOCK PAUL G [US]
US 5496346 A 19960305 - HORZEWSKI MICHAEL J [US], et al
US 5292331 A 19940308 - BONEAU MICHAEL D [US]
US 5674278 A 19971007 - BONEAU MICHAEL D [US]
US 3657744 A 19720425 - ERSEK ROBERT A
US 4739762 A 19880426 - PALMAZ JULIO C [US]
US 5195984 A 19930323 - SCHATZ RICHARD A [US]
US 5879382 A 19990309 - BONEAU MICHAEL D [US]
US 6344053 B1 20020205 - BONEAU MICHAEL D [US]
WO 2017032840 A1 20170302 - JANSSEN PHARMACEUTICA NV [BE]
WO 2018065365 A1 20180412 - JANSSEN PHARMACEUTICA NV [BE]
PAL ET AL., MOL. CELL. BIOL., 2003, pages 7475
PAL ET AL., MOL. CELL. BIOL., 2004, pages 9630
WANG ET AL., MOL. CELL. BIOL., 2008, pages 6262
CHUNG ET AL., J BIOL CHEM, 2013, pages 5534
HSU ET AL., NATURE, vol. 525, 2015, pages 7558
ZHAO ET AL., NAT STRUCT MOL BIOL., vol. 16, 2009, pages 304
"Handbook of Clinical Drug Data", 2002, MCGRAW-HILL
"Principles of Drug Action", 1990, CHURCHILL LIVINGSTON
"The Pharmacological Basis of Therapeutics", 2001, MCGRAW HILL
"Remingtons Pharmaceutical Sciences", 2000, LIPPINCOTT WILLIAMS & WILKINS
MARTINDALE: "The Extra Pharmacopoeia", 1999, THE PHARMACEUTICAL PRESS
WUTS, PETER GMTHEODORA W. GREENE: "Greene's protective groups in organic synthesis", 2006, JOHN WILEY & SONS

Citation (search report)

[AD] WO 2017032840 A1 20170302 - JANSSEN PHARMACEUTICA NV [BE]
[A] WO 2016178870 A1 20161110 - LILLY CO ELI [US]
[A] WO 2015200680 A2 20151230 - EPIZYME INC [US]
[A] US 2016244475 A1 20160825 - TATLOCK JOHN HOWARD [US], et al
[IP] FABIAN HULPIA ET AL: "Synthesis of a 3'- C -ethynyl-[beta]- d -ribofuranose purine nucleoside library: Discovery of C7-deazapurine analogs as potent antiproliferative nucleosides", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 157, 29 July 2018 (2018-07-29), FR, pages 248 - 267, XP055509826, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2018.07.062

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Designated extension state (EPC)

BA ME

DOCDB simple family (publication)

WO 2019032859 A1 20190214; AU 2018313910 A1 20200305; AU 2018313910 B2 20221208; BR 112020002736 A2 20200728; CA 3072439 A1 20190214; CN 111527099 A 20200811; CN 111527099 B 20240322; DK 3665179 T3 20210816; EP 3665179 A1 20200617; EP 3665179 B1 20210609; EP 3939986 A1 20220119; ES 2885180 T3 20211213; IL 272519 A 20200331; IL 272519 B 20220501; JP 2020530496 A 20201022; KR 20200036922 A 20200407; MA 49840 A 20200617; MX 2020001598 A 20201028; PL 3665179 T3 20211129; PT 3665179 T 20210910; UA 126481 C2 20221012; US 10570140 B2 20200225; US 11078205 B2 20210803; US 11208416 B2 20211228; US 2019048014 A1 20190214; US 2020148692 A1 20200514; US 2020361946 A1 20201119; US 2022153747 A1 20220519; ZA 202000773 B 20220727

DOCDB simple family (application)

US 2018046057 W 20180809; AU 2018313910 A 20180809; BR 112020002736 A 20180809; CA 3072439 A 20180809; CN 201880065979 A 20180809; DK 18760136 T 20180809; EP 18760136 A 20180809; EP 21178139 A 20180809; ES 18760136 T 20180809; IL 27251920 A 20200206; JP 2020530436 A 20180809; KR 20207006384 A 20180809; MA 49840 A 20180809; MX 2020001598 A 20180809; PL 18760136 T 20180809; PT 18760136 T 20180809; UA A202000927 A 20180809; US 201816059909 A 20180809; US 202016744771 A 20200116; US 202016985643 A 20200805; US 202117529781 A 20211118; ZA 202000773 A 20200205