EP 3941586 A4 20230315 - ARGININE GINGIPAIN INHIBITORS
Title (en)
ARGININE GINGIPAIN INHIBITORS
Title (de)
ARGININ-GINGIPAIN-INHIBITOREN
Title (fr)
INHIBITEURS DE L'ARGININE-GINGIPAÏNE
Publication
Application
Priority
- US 201962821926 P 20190321
- US 2020023994 W 20200320
Abstract (en)
[origin: WO2020191348A1] Therapeutics targeting the bacterium Porphyromonas gingivalis, including its proteases arginine gingipain A and arginine gingipain B, are disclosed, as well as the use thereof for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease. In certain embodiments, the invention provides compounds according to Formula I, Formula Ia, and Formula Ib, as described herein, and pharmaceutically acceptable salts thereof.
IPC 8 full level
A61P 31/04 (2006.01); C07C 279/12 (2006.01); C07C 279/24 (2006.01); C07D 213/68 (2006.01); C07D 213/82 (2006.01); C07D 239/34 (2006.01); C07D 261/12 (2006.01); C07D 279/28 (2006.01)
CPC (source: EP)
A61P 31/04 (2017.12); C07C 279/12 (2013.01); C07C 279/24 (2013.01); C07C 279/28 (2013.01); C07D 213/68 (2013.01); C07D 213/82 (2013.01); C07D 239/34 (2013.01); C07D 261/12 (2013.01); C07B 2200/07 (2013.01); C07C 2601/08 (2017.04)
Citation (search report)
- [XI] WO 2017083433 A1 20170518 - CORTEXYME INC [US]
- See references of WO 2020191348A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2020191348 A1 20200924; CA 3134518 A1 20200924; CN 113825542 A 20211221; EP 3941586 A1 20220126; EP 3941586 A4 20230315; JP 2022526897 A 20220527
DOCDB simple family (application)
US 2020023994 W 20200320; CA 3134518 A 20200320; CN 202080034237 A 20200320; EP 20773768 A 20200320; JP 2021556824 A 20200320