EP 3946311 A1 20220209 - ANESTHETIC COMPOSITION AND METHOD OF ANESTHETIZING THE EYE
Title (en)
ANESTHETIC COMPOSITION AND METHOD OF ANESTHETIZING THE EYE
Title (de)
ANÄSTHETISCHE ZUSAMMENSETZUNG UND VERFAHREN ZUR ANÄSTHETISIERUNG DES AUGES
Title (fr)
COMPOSITION ANESTHÉSIQUE ET PROCÉDÉ D'ANESTHÉSIE DE L'IL
Publication
Application
Priority
- US 2020022915 W 20200316
- US 201962824207 P 20190326
- US 2019024239 W 20190327
- US 202016811798 A 20200306
Abstract (en)
[origin: WO2020197816A1] A topical ophthalmic anesthetic composition includes a formulation with an amount of articaine to provide anesthetic properties when applied topically to the eye, and a pH, viscosity, osmolality, dissociation constant, and additives such as antioxidants, buffers, methylcellulose, to achieve efficacy and safety. The composition can contain articaine in amounts of about 4.0% w/v to about 12.0% w/v and have a pH of about pH 3.5 to pH 7.0. The buffer can be borate/mannitol complex obtained from boric acid or salt thereof and D-mannitol. The articaine formulations can achieve adequate anesthesia of the internal aspect of the eye wall by topical application, without the use of an injectable anesthetic. Exemplary implementations of the disclosure include formulations include articaine in an amount of at least 7.0% w/v, where the formulation is an aqueous solution, a gel, an ointment, or in an encapsulated form.
IPC 8 full level
A61K 31/245 (2006.01); A61K 31/38 (2006.01); A61K 31/381 (2006.01)
CPC (source: EP IL KR)
A61K 9/0048 (2013.01 - EP IL KR); A61K 9/08 (2013.01 - EP IL KR); A61K 31/381 (2013.01 - EP IL KR); A61K 47/02 (2013.01 - EP IL KR); A61K 47/10 (2013.01 - EP IL); A61K 47/12 (2013.01 - KR); A61K 47/183 (2013.01 - KR); A61K 47/26 (2013.01 - EP IL KR); A61K 47/38 (2013.01 - EP IL KR); A61P 23/02 (2018.01 - EP KR); A61P 27/02 (2018.01 - EP IL KR)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2020197816 A1 20201001; AU 2020245203 A1 20211111; BR 112021019039 A2 20211130; CA 3134531 A1 20201001; CN 114072139 A 20220218; EP 3946311 A1 20220209; EP 3946311 A4 20221228; IL 286624 A 20211031; JP 2022527621 A 20220602; KR 20210143254 A 20211126; MX 2021011589 A 20211215; SG 11202110423U A 20211028
DOCDB simple family (application)
US 2020022915 W 20200316; AU 2020245203 A 20200316; BR 112021019039 A 20200316; CA 3134531 A 20200316; CN 202080033483 A 20200316; EP 20776365 A 20200316; IL 28662421 A 20210923; JP 2021560140 A 20200316; KR 20217034148 A 20200316; MX 2021011589 A 20200316; SG 11202110423U A 20200316