EP 3953388 A1 20220216 - TRISPECIFIC BINDING PROTEINS, METHODS, AND USES THEREOF
Title (en)
TRISPECIFIC BINDING PROTEINS, METHODS, AND USES THEREOF
Title (de)
TRISPEZIFISCHE BINDUNGSPROTEINE, VERFAHREN UND IHRE VERWENDUNGEN
Title (fr)
PROTÉINES DE LIAISON TRISPÉCIFIQUES, PROCÉDÉS ET UTILISATIONS CONNEXES
Publication
Application
Priority
- US 201962831572 P 20190409
- EP 19306261 A 20191002
- US 2020027320 W 20200408
Abstract (en)
[origin: WO2020210392A1] Provided herein are trispecific and/or tri valent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation, and wherein and a second pair of polypeptides possess a single variable domain forming a single antigen binding site. In some embodiments, the binding proteins comprise a binding site that binds a CD28 polypeptide, a binding site that binds a CDS polypeptide, and a binding site that binds a third polypeptide, such as a tumor target protein. The disclosure also relates to methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.
IPC 8 full level
C07K 16/28 (2006.01); C12N 5/0783 (2010.01)
CPC (source: EP IL KR)
A61K 39/4611 (2023.05 - KR); A61K 39/464406 (2023.05 - KR); A61K 39/464429 (2023.05 - KR); A61P 31/12 (2018.01 - KR); A61P 35/00 (2018.01 - KR); C07K 14/7051 (2013.01 - KR); C07K 16/2809 (2013.01 - EP IL KR); C07K 16/2818 (2013.01 - EP IL KR); C07K 16/2896 (2013.01 - KR); C07K 16/32 (2013.01 - EP IL KR); A61K 2039/505 (2013.01 - KR); A61K 2121/00 (2013.01 - KR); A61K 2300/00 (2013.01 - KR); C07K 2317/31 (2013.01 - EP IL KR); C07K 2317/565 (2013.01 - EP IL); C07K 2317/64 (2013.01 - EP IL); C07K 2317/73 (2013.01 - EP IL KR); C07K 2317/92 (2013.01 - EP IL KR)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2020210392 A1 20201015; AU 2020272839 A1 20211202; BR 112021019915 A2 20211207; CA 3136821 A1 20201015; CN 113950484 A 20220118; CO 2021014918 A2 20211119; EP 3953388 A1 20220216; IL 286929 A 20211031; JP 2022527994 A 20220607; KR 20210149141 A 20211208; MX 2021012386 A 20220118; SG 11202111012Q A 20211129; TW 202104261 A 20210201
DOCDB simple family (application)
US 2020027320 W 20200408; AU 2020272839 A 20200408; BR 112021019915 A 20200408; CA 3136821 A 20200408; CN 202080041550 A 20200408; CO 2021014918 A 20211104; EP 20722422 A 20200408; IL 28692921 A 20211003; JP 2021559759 A 20200408; KR 20217036094 A 20200408; MX 2021012386 A 20200408; SG 11202111012Q A 20200408; TW 109111809 A 20200408